Antimicrob Agents Chemother 2011,55(5):2032–2041. 10.1128/AAC.01550-10308827721300839CrossRefPubMedCentralPubMed 16. Engström A, Perskvist N, Werngren J, Hoffner SE, Juréen P: Comparison of clinical isolates and in vitro selected mutants reveals that tlyA is not a sensitive genetic marker for capreomycin resistance in Mycobacterium tuberculosis . J Antimicrob Chemother 2011,66(6):1247–1254. 10.1093/jac/dkr10921427106CrossRefPubMed 17. Gikalo MB, Nosova EY, Krylova LY, Moroz AM: The role of eis mutations in
the development of kanamycin resistance in Mycobacterium tuberculosis isolates from the Moscow region. J Antimicrob Chemother 2012,67(9):2107–2109. 10.1093/jac/dks17822593564CrossRefPubMed 18. Aínsa JA, Blokpoel MCJ, Otal I, Young DB, De Smet KAL, Martín C: Molecular cloning and characterization of Tap, a putative multidrug efflux pump present APR-246 supplier in Mycobacterium fortuitum and Mycobacterium tuberculosis . J Bacteriol 1998,180(22):5836–5843. 1076559811639CrossRefPubMedCentralPubMed 19. Morris RP, click here Nguyen L, Gatfield J, Visconti K, Nguyen K, Schnappinger D, Ehrt S, Liu Y, Heifets L, Pieters J, Schoolnik G, Thompson CJ: Ancestral antibiotic resistance in Mycobacterium tuberculosis . Proc Natl Acad Sci U S A 2005,102(34):12200–12205. 10.1073/pnas.0505446102118602816103351CrossRefPubMedCentralPubMed
selleck compound 20. Maus CE, Plikaytis BB, Shinnick TM: Molecular analysis of cross-resistance to capreomycin, kanamycin, amikacin, and viomycin in Mycobacterium tuberculosis . Antimicrob Agents Chemother 2005,49(8):3192–3197. 10.1128/AAC.49.8.3192-3197.2005119625916048924CrossRefPubMedCentralPubMed 21. Via
LE, Cho SN, Hwang S, Bang H, Park SK, Kang HS, Jeon D, Min SY, Oh T, Kim Y, Kim YM, Rajan V, Wong SY, Shamputa IC, Carroll M, Goldfeder L, Lee SA, Holland SM, Eum S, Lee H, Barry CE: Polymorphisms associated with resistance and cross-resistance to aminoglycosides and capreomycin in Mycobacterium tuberculosis isolates from south korean patients with drug-resistant tuberculosis. J Clin Microbiol 2010,48(2):402–411. 10.1128/JCM.01476-09281558620032248CrossRefPubMedCentralPubMed 22. Akbergenov R, Shcherbakov D, Matt T, Duscha S, Meyer M, Wilson DN, Böttger EC: Molecular basis for selectivity of antituberculosis compounds capreomycin and viomycin. Antimicrob Pembrolizumab Agents Chemother 2011,55(10):4712–4717. 10.1128/AAC.00628-11318700521768509CrossRefPubMedCentralPubMed 23. Johansen SK, Maus CE, Plikaytis BB, Douthwaite S: Capreomycin binds across the ribosomal subunit interface using tlyA -encoded 2′-O-methylations in 16S and 23S rRNAs. Mol Cell 2006,23(2):173–182. 10.1016/j.molcel.2006.05.04416857584CrossRefPubMed 24. Maus CE, Plikaytis BB, Shinnick TM: Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis . Antimicrob Agents Chemother 2005,49(2):571–577. 10.1128/AAC.49.2.571-577.200554731415673735CrossRefPubMedCentralPubMed 25.