(PDF 27 KB) References 1. Stewart PS, Franklin MJ: Physiological heterogeneity in biofilms. Nat Rev Microbiol 2008, 6:199–210.PubMedCrossRef 2. Whiteley M, Bangera MG, Bumgarner RE, Parsek MR, Teitzel GM, Lory S, Greenberg EP: Gene expression in Pseudomonas aeruginosa biofilms. Nature 2001, 413:860–864.PubMedCrossRef 3. An D, Parsek MR: The promise and peril check details of transcriptional profiling in biofilm communities. Curr Opin Microbiol 2007, 10:292–296.PubMedCrossRef 4. Hentzer M, Eberl L, Givskov M: Transcriptome analysis of Pseudomonas aeruginosa biofilm development: anaerobic respiration and iron limitation. Biofilms
2005, 2:37–61.CrossRef 5. Waite R, Paccanaro A, this website Papakonstantinopoulou A, Hurst J, Saqi M, Littler E, Curtis M: Clustering of Pseudomonas aeruginosa transcriptomes from planktonic cultures, developing and mature biofilms reveals distinct expression profiles. BMC Genomics 2006, 7:162.PubMedCrossRef 6. Waite RD, Papakonstantinopoulou https://www.selleckchem.com/products/GSK1904529A.html A, Littler E, Curtis MA: Transcriptome analysis of Pseudomonas aeruginosa growth: Comparison of gene expression
in planktonic cultures and developing and mature biofilms. J Bacteriol 2005, 187:6571–6576.PubMedCrossRef 7. Patell S, Gu M, Davenport P, Givskov M, Waite RD, Welch M: Comparative microarray analysis reveals that the core biofilm-associated transcriptome of Pseudomonas aeruginosa comprises relatively few genes. Environ Microbiol Rep 2010, 2:440–448.CrossRef 8. Mah T-F, O’Toole GA: Mechanisms of biofilm resistance to antimicrobial agents. Trends Microbiol 2001, 9:34–39.PubMedCrossRef 9. Ochsner UA, Wilderman PJ, Vasil AI, Vasil ML: GeneChip expression analysis of the iron starvation response in Pseudomonas aeruginosa : identification of novel pyoverdine biosynthesis genes. Mol Microbiol 2002, 45:1277–1287.PubMedCrossRef 10. Lenz AP, Williamson KS, Franklin MJ: Localized gene expression in Pseudomonas aeruginosa biofilms. Appl Environ Microbiol 2008, 74:4463–4471.PubMedCrossRef 11. Perez-Osorio AC, Williamson KS, Franklin MJ: Heterogeneous rpoS and
rhlR mRNA levels and 16S rRNA/rDNA (rRNA gene) ratios within Pseudomonas aeruginosa biofilms, sampled by laser capture microdissection. J Bacteriol 2010, 192:2991–3000.PubMedCrossRef 12. Borriello G, Werner E, Roe F, Kim AM, Ehrlich GD, Stewart PS: Oxygen limitation contributes to antibiotic tolerance of Pseudomonas aeruginosa PLEK2 in biofilms. Antimicrob Agents Chemother 2004, 48:2659–2664.PubMedCrossRef 13. Walters MC, Roe F, Bugnicourt A, Franklin MJ, Stewart PS: Contributions of antibiotic penetration, oxygen limitation, and low metabolic activity to tolerance of Pseudomonas aeruginosa biofilms to ciprofloxacin and tobramycin. Antimicrob Agents Chemother 2003, 47:317–323.PubMedCrossRef 14. Werner E, Roe F, Bugnicourt A, Franklin MJ, Hayden A, Molin S, Pitts B, Stewart PS: Stratified growth in Pseudomonas aeruginosa biofilms. Appl Environ Microbiol 2004, 70:6188–6196.PubMedCrossRef 15.