(c) 2010 American Institute of Physics. [doi:10.1063/1.3480987]“
“Several protease inhibitors have reached the world market in the last fifteen years, dramatically improving the quality of life and life expectancy of millions of HIV-infected patients. In spite of the tremendous HTS assay research efforts in this area, resistant HIV-1 variants are constantly decreasing the ability of the drugs to efficiently inhibit the enzyme. As a consequence, inhibitors with novel frameworks are necessary to circumvent resistance to chemotherapy.

In the present work, we have created 3D QSAR models for a series of 82 HIV-1 protease inhibitors employing the comparative molecular field analysis (CoMFA) method. Significant correlation coefficients

were obtained (q(2) = 0.82 and r(2) = 0.97), indicating the internal consistency of the best model, which was then used to evaluate an external test set containing 17 compounds. The predicted values were in good agreement with the experimental results, showing the robustness of the model and its substantial predictive power for untested compounds. The final QSAR model and the information gathered from the CoMFA contour maps should be useful for the design of novel anti-HIV agents with improved potency.”
“An ethnobotanical survey of herbal medicine used for treatment of malaria fever in 17 communities in Ogun State, Southwest Nigeria was carried out. According to the results, 38 plant species belonging to 24 families were used in herbal

Selleck AZD0530 antimalarial recipes. Among the plants mentioned, the most frequently used were Morinda lucida (7.87%), Lawsonia inermis (7.41%), Citrus medica (6.94%), Sarcocephalus latifolius (6.48%) and Morinda morindiodes (6.48%). Investigations were carried out on the plant part (leaf, stem or root) used, method of preparing herbal antimalarial remedies SRT2104 mw and how it is administered. Result showed that irrespective of plant and part (leave, fruit, stem bark or root bark) or combinations of the plant parts, water and aqueous extract from fermented maize were the main medium of herbal antimalarial preparations. Treatment regimens of malaria generally included drinking, bathing and steam inhalation of the aqueous herbal preparations for 4 – 10 days or until symptoms of malaria disappear. About 65% of all the plants mentioned in the survey have been documented to have toxic effect on the liver and kidney of experimental mice. Continuous consumption of these plants could therefore have pathological effects on the consumers. Hence, this show the need for more research in order to identify lead compounds in indigenous antimalarial plants with less or no toxicity.