CONCLUSIONS The TLR3 412Phe variant confers protection against geographic atrophy, probably by suppressing the death of retinal pigment epithelial cells. Since double- stranded RNA ( dsRNA) can activate TLR3- mediated apoptosis, our results suggest a role of viral dsRNA in the development of geographic atrophy and E7080 point to the potential toxic effects of short- interfering- RNA therapies in the eye.”
“Pathogenic circulating vaccine-derived polioviruses (cVDPVs)
have become a major obstacle to the successful completion of the global polio eradication program. Most cVDPVs are recombinant between the oral poliovirus vaccine (OPV) and human enterovirus species C (HEV-C). To study the role of HEV-C sequences in the phenotype of cVDPVs, we generated a series of recombinants between a Madagascar cVDPV isolate and its parental OPV type 2 strain. Results indicated that the HEV-C sequences present in this cVDPV contribute to its characteristics, including pathogenicity, suggesting that interspecific recombination contributes to the phenotypic biodiversity of polioviruses NVP-BSK805 cell line and may favor the emergence of cVDPVs.”
“Background The value of continuous glucose monitoring in the management of type 1 diabetes mellitus has not been determined.
Methods In a multicenter clinical
trial, we randomly assigned 322 adults and children who were already receiving intensive therapy for type 1 diabetes to a group with continuous glucose monitoring or to a control group performing home monitoring with a blood glucose meter. All the patients were stratified into three groups according to age and had a glycated hemoglobin level of 7.0 to 10.0%. The primary outcome was the change in the glycated hemoglobin level at 26 weeks.
Results The changes in glycated hemoglobin levels in the two study
groups varied markedly according to age group ( P = 0.003), with a significant AMP deaminase difference among patients 25 years of age or older that favored the continuous- monitoring group ( mean difference in change, – 0.53%; 95% confidence interval [ CI], – 0.71 to – 0.35; P< 0.001). The between- group difference was not significant among those who were 15 to 24 years of age ( mean difference, 0.08; 95% CI, – 0.17 to 0.33; P = 0.52) or among those who were 8 to 14 years of age ( mean difference, – 0.13; 95% CI, – 0.38 to 0.11; P = 0.29). Secondary glycated hemoglobin outcomes were better in the continuous- monitoring group than in the control group among the oldest and youngest patients but not among those who were 15 to 24 years of age. The use of continuous glucose monitoring averaged 6.0 or more days per week for 83% of patients 25 years of age or older, 30% of those 15 to 24 years of age, and 50% of those 8 to 14 years of age. The rate of severe hypoglycemia was low and did not differ between the two study groups; however, the trial was not powered to detect such a difference.