Magnesium may also prevent narrowing of brain blood vessels caused by the neurotransmitter serotonin. Daily oral magnesium has also been shown to be effective in preventing menstrually related migraine, especially in those with premenstrual migraine. This means that preventive use can be targeted at those with aura and/or those with menstrually related migraine. It is difficult

to measure magnesium levels accurately, as levels in the blood stream may represent only 2% of total body stores, with the rest of https://www.selleckchem.com/products/Fludarabine(Fludara).html magnesium stored in the bones or within cells. Most importantly, simple magnesium blood levels do not give an accurate measure of magnesium levels in the brain. This has led to uncertainty concerning whether correcting a low magnesium level is necessary in treatment, or whether magnesium effectiveness is even related to low blood levels in the first place. Measurement of ionized LBH589 cell line magnesium or red blood cell magnesium levels is thought to possibly be more accurate, but these laboratory tests but are more difficult

and expensive to obtain. Because magnesium may not be accurately measured, low magnesium in the brain can be difficult to prove. Those prone to low magnesium include people with heart disease, diabetes, alcoholism, and those on diuretics for blood pressure. There is some evidence that migraineurs may have lower Etofibrate levels of brain magnesium either from decreased absorption of it in food, a genetic tendency to low brain magnesium, or from excreting it from the body to a greater degree than non-migraineurs. Studies of migraineurs have found low levels of brain and spinal fluid magnesium in between migraine attacks. In 2012, the American Headache Society and the American Academy of Neurology reviewed the studies on medications used for migraine prevention and gave magnesium a Level B rating, that is, it is probably effective and should be considered

for patients requiring migraine preventive therapy. Because of its safety profile and the lack of serious side effects, magnesium is often chosen as a preventive strategy either alone, or with other preventive medications. Magnesium has also been studied for the acute, as-needed treatment of severe, difficult-to-treat migraine. Magnesium sulfate given intravenously was found to be most effective in those with a history of migraine with aura. In those without a history of aura, no difference was seen in immediate pain relief or nausea relief by magnesium, but there was less light and noise sensitivity after the infusion. Magnesium oxide, in tablet form, is very inexpensive, does not require a prescription, and may be considered as very reasonable prevention in those who have a history of aura, menstrually related migraine, no health insurance, or who may become pregnant.