Reaction time The participants must respond to a yellow spot appearing in the screen by moving the hand away from the press pad button. Reaction time is divided between a single point and a five-choice reaction time phase. Reaction time primarily measures processing speed. Outcome measures were reaction time (the speed with which the subject releases the press pad button in response to the onset of a ON-01910 molecular weight stimulus in either a single location or a five-choice location);

Inhibitors,research,lifescience,medical and movement time (the time taken to touch the stimulus after the press pad button has been released in trials in which stimuli appear in a single location or a five-choice location). A lower score is better for both tests. Outcome measures were also accuracy scores (the total number of trials in which the response is recorded as correct for assessment trials in which the stimuli appear Inhibitors,research,lifescience,medical in a single or a five-choice

location), with a higher score being better. Spatial working memory A number of colored boxes are shown on the touch screen. By touching the screen and using a process of elimination, the participant searches for Inhibitors,research,lifescience,medical blue ‘tokens’ in the boxes. Participants are instructed not to return to a box where a token has been found previously. The number of boxes is gradually increased to a maximum number of eight. Spatial working memory primarily measures working memory. Outcome measures were between errors (defined as times the subject revisits a box in which a token has previously been found); within errors (defined as the number of errors made within a search, that is, the number of times a subject revisits a box already found to be empty during the same search); strategy (counting the number of times Inhibitors,research,lifescience,medical the subject begins a new search with a different box for six- and eight-box problems only); mean time to first Inhibitors,research,lifescience,medical response (the mean time between the problem being presented to the subject and the subject first touching the screen to open a box); and

mean time to last response (the time between the problem being presented to the subject and the subject’s last screen touch to open a box to locate the final token for the problem). A lower score was better for all tests. Verbal recognition/recognition memory Participants are instructed to remember words, a total of 15, presented individually on the screen in front of them. PAK6 Participants are asked to recall as many of the presented words initially after the presentation. Twenty minutes after the initial recall phase, a second retrieval phase, a recognition test is conducted. Words are presented sequentially and participants are asked to press ‘yes’ or ‘no’, according to their recognition of the words as being presented previously or not. Verbal recognition/recognition memory primarily measures verbal learning and memory.