Results: Three of the patients had diarrhea, one had rectal bleeding, and one had both. The endoscopic findings revealed that two of the patients had edematous mucosa, red spots, erosions and ulcers in their colon, and that other patients had no mucosal lesions. We treated all the patients with antimicrobial eradication therapy. We used metronidazole for the therapy according to the results of the antimicrobial susceptibility tests. After the eradication therapy, the symptoms disappeared in four of the patients. Follow-up colonoscopy showed that mucosal lesions had disappeared in both of the two patients, and B. pilosicoli turned negative by histopathological and culture examinations. Conclusion: The pathogenesis

of B. pilosicoli and B. aalborgi is uncertain. B. pilosicoli Akt inhibitor infection causes various intestinal symptoms with relatively high incidence, though most patients

with B. aalborgi infection are asymptomatic. B. aalborgi may be commensal in the human intestine. In this study, we treated five HIS patients with antimicrobial eradication therapy, after which their clinical symptoms disappeared in four of the five patients. These cases suggest that B. pilosicoli-positive HIS patients with intestinal symptoms should be treated with a ntimicrobial eradication therapy. Key Word(s): 1. human intestinal spirochetosis; 2. Bracyspira pilosicoli; 3. Brachyspira aalborgi Presenting Author: WOONG SUN YOO Additional Authors: SOO HYUN YANNG, WONHYEONG PARK, DO YOUNG, SEO YOUNG YAMG, TAEGEYON KIM Corresponding Author: CP-673451 WOONG SUN YOO Affiliations: Veterans Health Service Medical Center, Veterans Health Service Medical Center, Veterans Health Service Medical Center, Veterans Health Service Medical Center, Veterans Health Service Medical Center Objective: Uncovered

metal stents rather than covered metal stents are commonly used for palliation of biliary obstruction secondary to peripancreatic cancer because of the low risk of stent migration. But de nove two third PTFE-covered nitinol stent have advantage at low reintervention rate and 上海皓元 safty because both large and silicone covering prevents leakage and tissue ingrowth. The goal of this study was to evaluate the safety and efficacy of de nove two third PTFE-covered nitinol stent for the palliative treatment of malignant biliary obstruction. Methods: Five patients (mean age 69.2 years) with peripancreatic cancer were retrospectively involved and underwent endoscopic retrograde cholangiopancreatography and newly designed two third PTFE partially covered self-expandable metal stents placement. The de nove partially covered SEMS (Niti-S stent; Taewoong Medical) is made with triple layer which is an PTFE (polytetrafluoroethylene) membrane sandwiched between two uncovered nitinol wires. Silicone covering prevents the risk of tumor ingrowth. Differently then traditional, this stent was longer coverd.