These HGMNCs contained iron oxide (Fe3O4) AZD4547 mouse nanoparticles with an average particle size of about 22 nm, as observed by transmission electron microscopy. The dielectrical properties of the pure hydrogel (HG); the hydrogel loaded with iron
ions, or the hydrogel iron-ion composite (HGIC); and the HGMNCs were measured. These results suggest that HGMNCs exhibited higher dielectric constants compared to HG and HGICs. The curcumin loading and release characteristics were also measured for HG, HGIC, and HGMNC systems. These data revealed that there was a sustained release of curcumin from HGMNCs because of the presence of magnetic nanoparticles in the hydrogel networks. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 122: 1364-1375, 2011″
“Background: beta(2)-Adrenergic receptor (beta(2)-AR) is a susceptibility locus for hypertension, and polymorphisms at this site relate to salt sensitivity and low https://www.selleckchem.com/products/SB-202190.html plasma renin activity (PRA). The Dietary Approaches to Stop Hypertension (DASH) dietary pattern lowers blood pressure and appears to interact with the renin-angiotensin-aldosterone system (RAAS).
Objective: We hypothesized that the DASH diet associates with increased RAAS activity, and genotype status at beta(2)-AR G46A modifies this response.
Design: We genotyped participants in the DASH-Sodium study (n = 372) at beta(2)-AR G46A to determine the association with blood pressure, RAAS components, and consumption of
the DASH diet. We used 2-way mixed linear regression and an additive model for all primary analyses.
Results: Mean (+/-SEM) PRA was significantly higher in participants in the DASH group than in participants in the control group (0.68 +/- 0.03 compared with 0.54 +/- 0.03 ng . mL(-1) . h(-1), P = 0.002). Serum aldosterone, urinary aldosterone, and urinary potassium concentrations were also significantly higher in the DASH group (P, 0.01 for all). learn more We observed significant gene-diet interactions for changes in systolic blood pressure (SBP) and concentrations of aldosterone and urinary potassium (P for
interaction = 0.048, 0.017, and 0.001 for SBP and aldosterone and urinary potassium concentrations, respectively). There was an association between the A allele of beta(2)-AR G46A and greater blood pressure reduction and blunted aldosterone and PRA responses to the DASH diet.
Conclusions: Our results indicate that the DASH diet lowers blood pressure and increases PRA and aldosterone concentrations. There is an association between the G46A polymorphism of beta(2)-AR and blood pressure and RAAS responses to the DASH diet, which suggests that beta(2)-AR may be a genetic modifier of DASH-diet responsiveness. This trial was registered at clinicaltrials.gov as NCT00000608. Am J Clin Nutr 2010; 92:444-9.”
“Tb(6)Fe(1-x)C(o)xBi(2) (x = 0, 0.125, 0.250, 0.375) compounds have been synthesized, and the structural and magnetic properties are reported.