Valence, valence-arousal, and approach-avoidance models of emotion were not as clearly supported. There was evidence that these factors are likely important components of emotion but that they could not fully account for the pattern of results. Most emotion elicitations were effective, although the efficacy varied with the emotions being compared. Picture presentations were
overall the most effective elicitor of discrete emotions. Stronger effects of emotion elicitations were associated with happiness versus negative emotions, Selleck GSK621 self-reported experience, a greater proportion of women (for elicitations of happiness and sadness), omission of a cover story, and participants alone versus in groups. Conclusions are limited by the inclusion of only some discrete emotions, exclusion of studies that did not elicit discrete emotions, few available effect sizes for some contrasts and moderators, and the methodological rigor of included studies.”
“Theiler murine encephalomyelitis virus (TMEV) infection of a mouse’s central nervous system is biphasic: first the virus infects motor neurons (acute phase),
and this is followed by a chronic phase in which the virus infects glial cells (primarily microglia and macrophages [M-phi]) of the spinal cord white matter, leading to inflammation and demyelination. As such, TMEV-induced demyelinating disease in mice provides a highly relevant experimental animal model for multiple sclerosis. Mathematical Selleck CRT0066101 ADAMTS5 models have proven valuable in understanding the in vivo dynamics of persistent virus infections, such as HIV-1, hepatitis B virus, and hepatitis C virus infections. However, viral dynamic
modeling has not been used for understanding TMEV infection. We constructed the first mathematical model of TMEV-host kinetics during acute and early chronic infections in mice and fit measured viral kinetic data with the model. The data fitting allowed us to estimate several unknown parameters, including the following: the rate of infection of neurons, 0.5 x 10(-8) to 5.6 x 10(-8) day(-1); the percent reduction of the infection rate due to the presence of virus-specific antibodies, which reaches 98.5 to 99.9% after day 15 postinfection (p.i.); the half-life of infected neurons, 0.1 to 1.2 days; and a cytokine-enhanced macrophage source rate of 25 to 350 M-phi/day into the spinal cord starting at 10.9 to 12.9 days p.i. The model presented here is a first step toward building a comprehensive model for TMEV-induced demyelinating disease. Moreover, the model can serve as an important tool in understanding TMEV infectious mechanisms and may prove useful in evaluating antivirals and/or therapeutic modalities to prevent or inhibit demyelination.”
“In 2 meta-analyses involving 58 studies and 59,575 participants, we quantitatively summarized the relative reliability and validity of continuous (i.e., dimensional) and discrete (i.e.