g. impact speed, angle, and mass, can be used as the basis for defining standards for impact tests. Some of the main real world in-depth accidents studies across Europe include the “German In Depth investigation Accident Study” (GIDAS) [10] in Germany, the Co-operative Crash Injury Study (CCIS) [11] and

“On The Spot” (OTS) [12] in the United Kingdom, the “In-Depth Car Accident Analysis” (EDA) of INRETS in France [13] and the SafetyNet project operating until 2008 in six European countries [14]. For the in-depth study of road accidents focused on the PTW, the “Motorcycle Accident In depth Study” (MAIDS) [15] project is the reference Inhibitors,research,lifescience,medical for this type of vehicles. In the United States the “National Accident Sampling System “(NASS) [16] and the “Crash Injury Research and Engineering Network“ (CIREN) [17] are the main in-depth

accident research systems, and in Japan there is a collaborative study by “Japan Automobile Research Institute“ (JARI), Nippon Medical School Chiba Inhibitors,research,lifescience,medical Hokuso Hospital, and the “Institute for Traffic Accident Research and Data Analysis” (ITARDA) [18]. All this information can be useful for a Inhibitors,research,lifescience,medical wide range of fields of research such as ‘vehicle design for active and passive safety,’ ‘biomechanics,’ ‘driver behaviour,’ ‘trauma medicine,’ ‘road design,’ and so on. The data is also used for recognizing and assessing potential areas of future safety developments, evaluating vehicle safety performance in real world accident situations, and supporting

and validating computer simulations. For example, statistical data on important factors, e.g. impact Inhibitors,research,lifescience,medical speed, angle, and mass, can be used as the basis for defining standards for impact tests, but also to develop new devices Inhibitors,research,lifescience,medical or shapes to mitigate the injuries, to improve current triage Epigenetic inhibitor order operations, to develop and validate new tools for the prediction of the severity of the injuries [19,20] and to evaluate the change produced by the countermeasures adopted. In Italy, the collection and study of in-depth real world accident data has been very time limited in the past, and completely absent in the Tuscany region. The Chlormezanone projects conducted in Italy are the MAIDS project, led in the Pavia province between 1999 and 2001 and focusing on PTW vehicles, and the SafetyNet project conducted in the Marche region between 2004 and 2008, where all types of road accident data were collected. Due to the importance of the data coming from this type of study and the current absence in Italy of similar research, a medical-engineering network has been created. In the “methods” section, our modus operandi is explained, and a case study is introduced step-by-step. In the “results” section, the main results on the analysis of the road accidents currently studied are shown. In the “discussion” section, some preliminary consideration deductible from the previous results are highlighted.