We exemplify this model through a robot passively observing an ob

We exemplify this model through a robot passively observing an object to learn its features and movements. During the learning process of observing sensorimotor primitives, i.e., observing a set of trajectories of arm movements and its oriented object features, the pre-symbolic representation is self-organized in the parametric units. These representational units act as bifurcation parameters, guiding the robot to recognize and predict various learned sensorimotor primitives. The pre-symbolic representation also accounts for the learning of sensorimotor primitives in a latent learning context.”

sample DNA amplification was done by using a novel rotary-linear motion polymerase Rapamycin ZD1839 chain reaction (PCR) device. A simple compact disc was used to create the stationary sample chambers which are individually temperature controlled. The PCR was performed by shuttling the samples to different temperature

zones by using a combined rotary-linear movement of the disc. The device was successfully used to amplify up to 12 samples in less than 30 min with a sample volume of 5 mu l. A simple spring loaded heater mechanism was introduced to enable good thermal contact between the samples and the heaters. Each of the heater temperatures are controlled by using a simple proportional-integral-derivative pulse width modulation control system. The results show a good improvement in the amplification rate and duration of the samples. The reagent volume used was reduced to nearly 25% of that used in conventional

method. (C) 2012 American Institute of Physics. [http://dx.doi.org.elibrary.einstein.yu.edu/10.1063/1.3690469]“
“Background: Musculoskeletal injuries of the shoulder in paraplegic patients with long-term survival can result from overuse and/or inappropriate use of wheelchairs. The purpose of the present study was to evaluate the prevalence and risk of pathological changes in the weight-bearing shoulder girdle of paraplegic patients who have been wheelchair-dependent for more than thirty years in comparison with able-bodied volunteers.

Methods: QNZ in vivo One hundred paraplegic patients were matched for sex and age with a group of 100 able-bodied volunteers. Two hundred shoulders from each group were evaluated with use of magnetic resonance imaging. Collected outcome measures included a standardized clinical examination protocol, the Constant score, and a visual analog score for pain intensity.

Results: Shoulder function according to the Constant score was significantly worse in the paraplegic patients than in the able-bodied volunteers. Similarly, the visual analog scale pain scores were significantly worse for the paraplegic patients.

Conclusions: From these results we can identify patients who are

Conclusions: From these results we can identify patients who are at a higher risk of developing DAH after allo-HSCT, and we found that high-dose corticosteroid therapy may not alter the poor outcome associated with this syndrome. Copyright (C) 2012 S. Karger AG, Basel”

Hypertrophic scars (HScs) are inelastic scars that can cause functional loss and disfigurement. Decorin regulates collagen fibrillogenesis, and its expression is lower in HScs than in normal skin and during wound healing.


To evaluate the efficacy of combined verapamil and triamcinolone in treating HScs.



human HSc fragments from surgically treated burned patients were divided into three groups: A (normal saline), B (verapamil), and C (verapamil and triamcinolone). The specimens were bilaterally implanted in the back of nude mice, treated using intralesional injections, and observed for BLZ945 Protein Tyrosine Kinase inhibitor 4 weeks. We compared the fibroblast viability and proliferation, decorin staining, and scar weights to evaluate treatment efficacy.


Viability and proliferation of HSc fibroblasts from groups B and C were significantly lower at all time intervals HM781-36B after transplantation (p <.001).

Treatment (Groups B and C) stimulated strong decorin staining by 4 weeks. Nonsignificant differences in changes in scar weight were observed between groups.


We present the first evidence of verapamil-augmented decorin expression spatially correlated with collagen bundles in HScs. Combination therapy can reduce the dosage of each drug but achieve equal Bcl-2 inhibitor or better efficacy than monotherapy, reducing the side effects of a single drug.

The authors have indicated no significant interest with commercial supporters.”
“Background: Breathing pattern description and chest wall kinematics during phonation have not been studied in male

and female patients with chronic obstructive pulmonary disease. Objectives: We used optoelectronic plethysmography to provide a quantitative description of breathing pattern and chest wall kinematics. Methods: Volumes of chest wall compartments (rib cage and abdomen) were assessed in 15 patients while reading aloud (R), singing (SI) and during high-effort whispering (HW). Results: Relative to quiet breathing, tidal volume and expiratory time increased while inspiratory time decreased. The expiratory flow decreased during R and SI, but was unchanged during HW. In males, the end-expiratory volume decreased as a result of a decreased volume of rib cage during R, SI and HW and due to a decreased volume of abdomen during HW. In females, a decrease in end-expiratory volume was accomplished by a decrease in abdominal volume during R and HW. During R, the chest wall end-expiratory volume of the last expiration in females was to the left of the maximal expiratory flow volume D curve (MEFV), with still substantial expiratory reserve volume available.

It is hoped that development of biomarkers to identify CM patient

It is hoped that development of biomarkers to identify CM patients and potential risk for adverse outcomes would greatly enhance better intervention and clinical management to improve the outcomes. We review here what is currently known regarding biomarkers for CM outcomes.

A Pub Med literature search was performed using the following search terms: “”malaria,”" “”cerebral malaria,”" “”biomarkers,”" “”mortality”" and “”

neurological sequelae.”" This search revealed a paucity of usable biomarkers for CM management. We propose three main LBH589 areas in which researchers can attempt to identify CM biomarkers: 1) early biomarkers, 2) diagnostic biomarkers and 3) prognostic biomarkers.”
“We report the growth of a Nd-doped calcium barium niobate (Nd:CBN-28) single crystal using the Czochralski method. The point group and space group of Nd:CBN-28 are determined to be tetragonal 4mm and P4bm, respectively, Bcl-2 lymphoma and the effective segregation coefficients of Nd, Ca, Ba, and Nb are 0.988, 1.029, 0.992, and 0.985, respectively. The density of the material is 5.321 g cm(-3) at 19.6 degrees C, in good agreement with the theoretical value. Thermal expansion measurements reveal that during the heating cycle, the c-axis of Nd:CBN-28 undergoes both thermal

contraction and thermal expansion, while at the same time there is only expansion along the a-axis. Specific heat measurements reveal that an anomaly appears at about 220 degrees C due to a phase transition. The thermal diffusivity

increases slowly with increasing temperature. The thermal conductivity of the crystal has been calculated from these results, and the phonon mean free paths l(a) and l(c) along the a- and c-axes of Nd:CBN-28 crystal are estimated. The transmission spectrum of Nd:CBN-28 crystal along the [001] direction has been measured.”
“Background: Disruption of developing immune and respiratory systems by early-life exposure to persistent organic pollutants (POPS) could result into reduced capacity to fight infections GSK1210151A ic50 and increased risk to develop allergic manifestations later in life.

Objectives: To systematically review the epidemiologic literature on the adverse effects of early-life exposure to POPs on respiratory health, allergy and the immune system in infancy, childhood and adolescence.

Methods: Based on published guidelines for systematic reviews, two independent researchers searched for published articles in MEDLINE ad SCOPUS using defined keywords on POPs and respiratory health, immune function and allergy. Study eligibility criteria were defined to select the articles.

Results: This review of 41 studies finds limited evidence for prenatal exposure to DDE, PCBs and dioxins and risk of respiratory infections. Evidence was limited also for postnatal exposure to PCBs, specifically ndl-PCBs, and reduced immune response after vaccination in childhood.

Methods One hundred patients undergoing mandibular


Methods. One hundred patients undergoing mandibular

osteotomy surgery were studied. Patients were allocated randomly to receive 1 of 2 treatment regimens: 0.15 mg/kg ondansetron or 0.5 mg/kg metoclopramide intravenously 30 minutes before extubation. All were adults and were treated by one surgeon and all operations were the same and lasted 2.5 to 3.0 hours. The patients were assessed at 3 time periods: 0 to 3 hours, 3 to SB203580 research buy 12 hours, and 12 to 24 hours postoperatively for emesis.

Result. The data from this study showed that during the first 24-hour postoperative period, patients receiving ondansetron following general anesthesia had an 11% (11 patients) incidence of emesis compared with 28% (22 patients) in the group that received metoclopramide.

Conclusion. In this study, ondansetron (0.1 mg/kg) was twice as effective in preventing postoperative vomiting compared with metoclopramide. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;111:275-277)”
“DC, AC conductivities and dielectric properties of high abrasion furnace carbon black (HAF)/acrylonitrile butadiene rubber

(NBR) composite have been studied with varying the aramide Stable Kevlar(R) fiber content, temperature, and frequency. Generally, the electrical conductivity was decreased with increasing Stable Kevlar(R) fiber content, which was confirmed by the positron annihilation lifetime spectroscopy. Negative temperature coefficient of conductivity (NTCC) behavior between 353 and 413 K was detected, except TGF-beta inhibitor for the composite containing 10 phr Kevlar which showed positive temperature coefficient of conductivity (PTCC) behavior above 383 K. These NTCC

and PTCC behaviors were further manifested by differential scanning calorimetry (DSC). For the composite with 10 phr Kevlar, ATPase inhibitor the interfacial polarization between the fibers and the polymeric composite can be ascribed to Maxwell-Wagner-Sillars mechanism. The (MWS) relaxation disappeared for higher fibers content. The analysis of the electric modulus in the frequency range from 1 kHz to 1 MHz shows that the interfacial relaxation obeys ColeDavison distribution of relaxation times. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012″
“Domain growth under the electric field of an atomic force microscope (AFM) is studied by piezoresponse force microscopy in congruent single-crystal LiTaO3 and compared to a finite element method simulation. The model is based on the existence of a conductive top layer, being the water absorbed layer always present in AFM experiments in air, within which the electric potential can propagate beyond the tip contact area. As a result, the simulated domain growth demonstrates kinetics in agreement with experimental observations, thus underlying the active role of the water layer. (C) 2011 American Institute of Physics. [doi:10.1063/1.3623762]“

2 0, Murex Biotech) was initiated at 12 months of age Infants we

2.0, Murex Biotech) was initiated at 12 months of age. Infants were categorized as EIA-negative (seroreverted; negative Genscreen), EIA-indeterminate (positive Genscreen, negative Murex), or EIA-positive (Genscreen and Murex positive).

Results: Of 273 infants included in the study, 59 (22%) were EIA-negative at 12 months, 131 (48%) were indeterminate, and 83 (30%) were EIA-positive; specificity 21.6 (95% confidence interval: 16.6, 26.3). Infants with positive EIAs at 12 months were 74% more likely than EIA-indeterminate infants to test indeterminate or positive at 18 months (risk

ratio, 1.74, 95% confidence interval: 1.15, 2.64; P = 0.03).

Conclusions: Expectations regarding infant seroreversion by standard EIAs should be reassessed to reflect potential cross-regional differences in their performance.”
“The nonisothermal degradation kinetics of the copolymer poly(O,O-diethyl-O-allylthiophosphate-co-acrylonitrile), Tariquidar datasheet which was synthesized with O,O-diethyl-O-allylthiophosphate and acrylonitrile, were studied by thermogravimetry/derivative

thermogravimetry techniques. The kinetic parameters, buy RSL3 including the activation energy and the pre-exponential factor of the copolymer degradation process, were calculated by the Kissinger and Flynn-Wall-Ozawa methods. The thermal degradation mechanism of the copolymer was also studied with the Satava-Sestak method. The results show that the activation energies were 1.38.17 kJ/mol with the Kissinger method and 141.63 kJ/mol with the Flynn-Wall-Ozawa method. The degradation of the copolymer followed a kinetic model of a phase boundary reaction and the kinetic equation could be expressed as G(alpha) = 1 – (1 – alpha)(4) [where G(alpha) is the integral function of conversion and alpha is the extent of conversion of the Aurora Kinase inhibitor reactant decomposed at time t]. The reaction order was 4. (C) 2009 Wiley Periodicals,

Inc. J Appl Polym Sci 115: 3705-3709, 2010″
“The effect of the buried Si-SiO2 interface on the transient enhanced diffusion (TED) of boron in silicon on insulator (SOI) structures has been investigated. To this purpose, boron marker layers were grown by chemical vapor deposition on Si and SOI substrates and implanted under nonamorphizing conditions with 40 keV Si+ ions. The experimental results clearly confirm that the Si-SiO2 interface is an efficient trap for the Si interstitial atoms diffusing out of the defect region. Based on these experiments, existing models for the simulation of B TED in silicon have been modified to include an additional buried recombination site for silicon interstitials. The simulation results provide an upper limit of similar to 5 nm for the recombination length of interstitials at the Si-SiO2 interface. (C) 2010 American Institute of Physics. [doi:10.1063/1.3369160]“
“The hallmark of sickle cell disease (SCD) is the acute painful vaso-occlusive crisis (VOC). Among SCD patients, vaso-occlusive pain episodes vary in frequency and severity.

41, respectively (P< 01) There was no significant difference

41, respectively (P<.01). There was no significant difference in patient behavior during surgery and no significant adverse effects of acetaminophen use.

CONCLUSION: Preoperative oral administration of acetaminophen 1.0 g was effective, convenient, safe, and cost effective in reducing intraoperative and postoperative pain in phacoemulsification performed using topical anesthesia.”
“Strained Si nanowires (NWs) are attractive for deeply-scaled complementary metal-oxide-semiconductor devices due to the combination of enhanced carrier mobility and

excellent electrostatic control as was demonstrated with trigate metal-oxide-semiconductor field effect transistors. The challenge in using strained Si NWs for devices is to preserve the elastic strain during the required processing Nepicastat solubility dmso steps. In this work we investigated the influence of fundamental processing steps like patterning and dopant ion implantation on the PF-6463922 Protein Tyrosine Kinase inhibitor structural and transport properties of strained Si layers and NWs on silicon-on-insulator (SOI) substrates. NWs with widths down to

35 nm, fabricated on 25 nm strained SOI and implanted to doses ranging from 5 x 10(14) to 2 x 10(15) ions/cm(2) were investigated. We show that strain conservation and a low sheet resistivity of 6.2 x 10(-4) Omega cm, close to the layer resistivity, can only be obtained if the NWs are patterned on doped layers. For NWs directly implanted to doses above 1 x 10(15) ions/cm(2), complete strain relaxation

and structural disorder by solid phase recrystallization were observed. In both cases, NWs with widths smaller than 55 nm exhibit an increased specific resistivity. (C) 2010 American Institute of Physics. [doi:10.1063/1.3520665]“
“The aim of this study was to determine associations between the ultrasonic appearance of Monarc suburethral slings and postoperative bladder symptoms at an average follow-up time of 11 months.

A prospective clinical audit was conducted on 98 patients after Monarc suburethral sling. The assessment included pelvic floor ultrasound to determine the gap between the sling and symphysis pubis, the angle formed by cranial and caudal ends of the sling at rest and on Valsalva, and the location of the sling relative to the urethra.

Patients who reported postoperative 5-Fluoracil research buy stress incontinence (SI) or urge incontinence (UI) had a significantly wider gap between the symphysis pubis and sling (P = 0.032 and P = 0.006, respectively).

A narrower gap between the tape and symphysis pubis is associated with both SI and UI cure. Tighter transobturator sling placement seems to be advantageous for the cure of both SI and UI.”
“PURPOSE: To compare phacoemulsification alone and phacoemulsification with micro-bypass stent implantation in eyes with primary open-angle glaucoma.

SETTING: Instituto di Fisiopatologia Clinica, Clinica Oculistica, Universita’ di Torino, Torino, Italy.

This program included learning seminars, psychometric assessments

This program included learning seminars, psychometric assessments, leadership goals, intersession activities, coaching/mentoring, and leadership projects.

Practice innovation: Not applicable.

Main outcome measures: PLI collected survey data in order to evaluate the effectiveness of the institute’s leadership development program. In addition, an external MI-503 evaluator was hired to conduct interviews with the pharmacy directors of the organization

which chose to pilot the program.

Results: The evaluations from the participants indicate that the leadership development program met many but not all of its initial objectives. Consistent with action research methodology, the faculty of the institute met to redesign some sections of the program in order to meet the established goals. Adjustments were made to different components of the program over the next 4 years. Evaluation data show that these revisions were successful. In addition, follow-up evaluations with participants showed a lasting impact of the program on both individual leadership skills and organizational outcomes.

Conclusion: Given the positive BLZ945 in vitro outcomes indicated

by the evaluation data used in this study, the work of PLI indicates that broader leadership skills can be identified and enhanced within a group of pharmacy managers.”
“Objective: Determination of the number and type of allergens needed to be tested in epidemiological studies is important in order to identify most of the sensitized subjects with a cost-effective approach. This study aimed to investigate the minimum skin prick test panel for the identification of at least 95% of the sensitized subjects with symptoms of

asthma and/ or allergic rhinitis (AR) in Ankara, Turkey. Methods: Skin prick buy TPCA-1 test results of 7492 patients who were referred to our outpatient clinic with clinical symptoms of asthma and/ or AR between 1991 and 2005 were evaluated retrospectively. Seven allergens were tested in all and 13 allergens in 4202 patients. The allergen group needed for detection of 95% of the sensitized subjects was determined for both the 7 and 13 allergen panels. The study protocol was approved by the local ethics committee of Hacettepe University. Results: The atopy prevalences in the whole study population and in 4202 patients tested with the 13 allergen panel were calculated as 32.2% and 42.6%, respectively. Three allergens (Phleum pratense, Dermatophagoides pteronyssinus and Artemisia vulgaris) within the 7 allergen panel were adequate for the identification of at least 95% of the sensitized subjects. Olea europae was added to the previous three allergens when the 13 allergen panel was applied. Conclusion: Three to four allergens are sufficient for identification at least 95% of sensitized subjects with asthma and/ or AR in Ankara, Turkey.”
“Purpose of review

Manganese (Mn) is an essential element, but can be neurotoxic when exceeding the homeostatic range.

Informed consent was given and bilateral kidneys were transplante

Informed consent was given and bilateral kidneys were transplanted buy RSL3 en bloc with both ureters and bladder. The patient’s bladder was augmented with the donor bladder and bilateral ureteroneocystotomies of small ureters was avoided. At 3 and 18 months post-transplantation, cystoscopies revealed a viable bladder with new vessels and normal donor bladder. Cystogram revealed no reflux. The bladder segment was reperfused via blood supply from both ureters and then from the recipient’s bladder. It seems that bladder transplantation en bloc with pediatric kidneys is a viable option for augmentation

of a small recipient bladder that allows avoidance of very small bilateral ureteroneocystotomies.”
“The cell surface glycoprotein KAI1/CD82 suppresses tumor growth and metastasis in animal models. This study aimed to evaluate the prognostic relevance of KAI1/CD82 protein expression in human gastric cancer. Primary gastric carcinomas (n = 271) with a mean clinical follow-up time of 48 months were immunostained using the monoclonal anti-KAI1/CD82 antibody G2. Staining was evaluated as negative versus positive for statistical analysis. KAI1/CD82 immunoreactivity was absent in 103/271 (38%) cases.

There was a trend towards KAI1/CD82 negativity in poorly differentiated cases (p = 0.0679). Moreover, KAI1/CD82-negative carcinomas were associated with a higher pT status (p = 0.0222), metastatic lymph node involvement (p = 0.0018) and a higher clinical tumor

stage (p = 0.0050). The median overall survival times of KAI1/CD82-negative and KAI1/CD82-positive gastric carcinomas were 20 and 37 months, respectively Selleckchem GF120918 BI 2536 purchase (p = 0.2305). These results are in line with the proposed function of KAI1/CD82 as a suppressor of tumor growth and metastasis. However, these data suggest that KAI1/CD82, as detected by immunohistochemistry, is of limited value as a prognostic marker for gastric cancer in routine histological workup.”
“Background: A key to making insecticide-treated nets (ITNs) a long-term, sustainable solution to the spread of malaria is understanding what drives their purchase and use. Few studies have analysed the determinants of demand for bed nets for malaria prevention at the household level, and in particular, how demand for nets compares with demand for other mosquito prevention methods.

Methods: This study uses a household survey to assess the determinants of demand for bed nets in an area of endemic malaria transmission in rural, southern Mozambique. The study looks at willingness to pay (WTP) for bed nets, net ownership, usage, and past purchase behaviour, alongside expenditure and frequency of use of alternate methods for malaria prevention.

Results: While overall net ownership in the sample is low, the evidence fails to suggest that poorer households are less likely to own bed nets, when controlling for covariates, nor does the likelihood of receiving a free net depend on socioeconomic status (SES).

The particles demonstrate fair ability to remove urea in human bl

The particles demonstrate fair ability to remove urea in human blood serum. The maximum removal efficiency was nearly 26%, when 200 mg of CM nanocomposites were allowed to agitate with 25 mL of urea solution of concentration 100 mg/dL. The CM nanocomposites could be easily

removed by applying moderate magnetic field. (C) 2009 Wiley Periodicals, Inc. JAK inhibitor J Appl Polym Sci 114: 3106-3109, 2009″
“Although functionally related proteins can be reliably predicted from phylogenetic profiles, many functional modules do not seem to evolve cohesively according to case studies and systematic analyses in prokaryotes. In this study we quantify the extent of evolutionary cohesiveness of functional modules in eukaryotes and probe the biological and methodological factors influencing our

estimates. We have collected various datasets of protein complexes and pathways in Saccheromyces cerevisiae. We define orthologous groups on 34 eukaryotic genomes and measure the extent of cohesive MK-8776 clinical trial evolution of sets of orthologous groups of which members constitute a known complex or pathway. Within this framework it appears that most functional modules evolve flexibly rather than cohesively. Even after correcting for uncertain module definitions and potentially problematic orthologous groups, only 46% of pathways and complexes evolve more cohesively than random modules. This flexibility seems partly coupled to the nature of the functional module because biochemical pathways are generally more cohesively evolving than complexes.”
“Background Hyaluronic acid (HA) is the most frequently injected filler for

soft tissue augmentation in the United States. Objective To systematically review published evidence for aesthetic use of small- and large-gel-particle HA. Methods and Materials Clinical data on find protocol anatomic area, level of evidence, patient population, trial design, endpoints, efficacy, and safety were extracted from PubMed. Results Fifty-three primary clinical reports were analyzed. The highest-quality efficacy evidence was for the nasolabial folds (NLFs), with 10 randomized, blind, split-face, comparative trials. Several randomized, blind trials supported treatment of the glabella, lips, and hands. Lower-level evidence (from studies with nonrandomized, open-label, or retrospective designs) was recorded for the nasojugal folds (tear troughs), upper eyelids, nose, infraorbital hollows, oral commissures, marionette lines, perioral rhytides, temples, and cheeks. Common adverse events (AEs) across anatomic areas were pain, bruising, swelling, and redness. Serious AEs were uncommon (8 events in 8 patients of 4,605 total patients) and were considered to be unrelated (7 events) or probably unrelated (1 event) to treatment.

16 [95% confidence interval 0 91-1 47] and hazard ratio: 1 31 [95

16 [95% confidence interval 0.91-1.47] and hazard ratio: 1.31 [95% confidence interval 0.90-1.93], respectively for the highest HbA(1c) tertile compared with the lowest).

Conclusion: These results suggest that HbA(1c) does not significantly predict all-cause and cardiovascular mortality in non-diabetic community-dwelling older adults. (C) 2009 Elsevier B.V. All rights reserved.”
“We systematically investigate the characteristics of an electrical oscillation observed in two-terminal vanadium dioxide (VO2) devices. These oscillations are observed at room temperature in a simple electrical circuit without

inductive components. The GANT61 circuit is composed only of a dc voltage source, the VO2 device, and a standard resistor connected in series with the device. We explain why the observed oscillations BMS-345541 are a result of the percolative metal-to-insulator transition

(MIT) of VO2 and the coexistence of the metal and insulating phases. Specifically, oscillations are attributed to the construction and destruction of capacitive regions composed of regions of the semiconducting phase, (as dielectric material) and metallic phase electron carriers, induced by the MIT (as capacitor electrodes). Since the coexistence of these phases-and thus the capacitive regions-is destroyed by elevated temperature, the MIT oscillation is not explained in terms of significant heat input but rather in terms of a voltage-triggered effect. It is also discussed whether the current jump CP-456773 mw at the onset of the oscillations is driven by Mott physics or by Peierls physics relying on a structural phase transition. Furthermore, the electrical parameter space surrounding these oscillations is explored, and a generation window is identified. Within this generation window, the oscillation frequency can be continuously tuned by adjusting applied voltage or by an external circuit component, such as resistor or added capacitor. The frequency of oscillations can be increased up to >1 MHz.”
“Constitutively active, ‘oncogenic’ H-RAS can drive proliferation and transformation in human

cancer, or be a potent inducer of cellular senescence. Moreover, aberrant activation of the Ras pathway owing to germline mutations can cause severe developmental disorders. In this study we have generated transgenic zebrafish that constitutively express low levels, or can be induced to express high levels, of oncogenic H-RAS. We observed that fish carrying the integrated transgene in their germline display several hallmarks of Costello syndrome, a rare genetic disease caused by activating mutations in the gene H-RAS, and can be used as a model for the disease. In Costello-like fish, low levels of oncogenic H-RAS expression are associated with both reduced proliferation and an increase in senescence markers in adult progenitor cell compartments in the brain and heart, together with activated DNA damage responses.