Multiple oesophageal

biopsies did not show evidence of dysplasia or malignancy. He presented with dysphagia in 2013. A diagnostic upper GI endoscopy showed stricture at 40 cm from incisor. The stricture was unsuccessfully treated with CRE wireguided TTO ballon dilatations (inflated up to 12 mm). Multiple biopsies confirmed high grade adenocarcinoma. CT staging, PET scan and EUS showed T3, N0, M0. He received pre-operative adjuvant chemotherapy followed by total oesophagectomy. Conclusion: Up to 90% of patients with EIPD have associated stenosis of the esophagus of various levels due to chronic oesophagitis from reflux disease. Metaplastic squamous epithelium had been found within the excretory ducts of esophageal submucosal glands in EIPD may be the link between EIPD LEE011 in vivo and esophageal carcinoma. The increased prevalence of EPID in patients with oesophageal carcinoma may warrant periodic surveillance in this small population

of patients. Key Word(s): 1. EPID; 2. Malignant stricture; Presenting Author: XUAN JIANG Additional Authors: HANLONG YAN, XINHUA PENG, YULAN LIU Corresponding Author: YULAN LIU Affiliations: Department of Gastroenterology, Peking University People’s Hospital Objective: To analyze the common symptoms and investigate the overlap rate of GERD CAL 101 and FBD in visited GI clinic in a general hospital. Methods: During April to June, 2011, Data collected were demographic information\chief complaints. A validated Chinese version Reflux Disease Questionnaire (RDQ) was used to assess the typical GER symptoms and diagnosed GERD. Reflux esopheagitis (RE) and non-erosive gastroesopheal reflux disease (NERD) were differentiate according to RDQ

scores\endoscopic diagnosis\PPI response. Lumacaftor manufacturer Functional bowl disease (FBD) was diagnosed using Rome III criteria. SPSS 17.0 programs were performed for statistical analyses. Results: 1074 (98.3%) finished questionnaire. The chief complaints in GI clinic patients included abdominal pain (32.5%, 12 missing cases), discomfort of abdomen (20.7%), abdominal bloating (13,7%), acid regurgitation and/or heartburn (17.3%), change in bowel habits (8.2%) and others. GER symptoms presented in 32.7% (351) of the subjects, and 10.0% (107) was diagnosed as GERD. 37.6% (404) of the subjecsts had chronic symptoms of abdominal pain/bloating, diarrhea/constipation; and 19.2% (207) was diagnosed as FBD. Higher RDQ scores of typical GER symptoms accompanied with higher rate of atypical GER symptoms in esophageal and extraesophageal (all P < 0.05), as well as the trend of increased possibility of comorbid symptoms of chronic bloating/constipation, and irritable bowl syndrome (IBS), functional constipation (FC) (trend chi-square test, all P < 0.05). Further, GERD patients presented with chronic bloating (27, 25.2%), chronic constipatin (15, 14.0%), and overlapping with IBS (11, 10.