Infect Immun 2010,78(8):3465–3474.PubMedCrossRef 4. Hackstadt T, Williams JC: Biochemical stratagem for obligate parasitism of eukaryotic cells by Coxiella burnetii . Proc Natl Acad Sci USA 1981,78(5):3240–3244.PubMedCrossRef 5. Omsland A, Heinzen RA: Life on the outside: the rescue of Coxiella burnetii from its host cell. Annu Rev Microbiol 2011, 65:111–128.PubMedCrossRef LCZ696 order 6. Coleman SA, Fischer ER, Howe D, Mead DJ, Heinzen RA: Temporal analysis of Coxiella burnetii morphological differentiation. J Bacteriol

2004,186(21):7344–7352.PubMedCrossRef 7. Gutierrez MG, Vazquez CL, Munafo DB, Zoppino FC, Beron W, Rabinovitch M, Colombo MI: Autophagy induction favours the generation and maturation of the Coxiella -replicative vacuoles. Cell Microbiol 2005,7(7):981–993.PubMedCrossRef learn more 8. Howe D, Melnicakova J, Barak I, Heinzen RA: Maturation of the Coxiella burnetii parasitophorous vacuole requires bacterial protein synthesis but not replication. Cell Microbiol 2003,5(7):469–480.PubMedCrossRef 9. Beare PA, Gilk SD, Larson CL, Hill J, Stead CM, Omsland A, Cockrell DC, Howe D, Voth DE, Heinzen RA: Dot/Icm type IVB secretion system requirements for Coxiella burnetii growth in human macrophages. MBio 2011,2(4):e00175–00111.PubMedCrossRef 10. Carey KL, Newton HJ, Luhrmann A, Roy CR: The

Coxiella burnetii Dot/Icm system delivers a unique repertoire of type IV effectors into host cells and is required for intracellular replication. PLoS Pathog 2011,7(5):e1002056.PubMedCrossRef 11. Voth DE, Beare PA, Howe D, Sharma UM, Samoilis G, Cockrell DC, Omsland A, Heinzen RA: The Coxiella burnetii cryptic plasmid is enriched in genes encoding type IV secretion system substrates. J Bacteriol 2011,193(7):1493–1503.PubMedCrossRef 12. Voth DE, Howe D, Beare PA, Vogel JP, Unsworth N, Samuel JE, Heinzen RA: The Coxiella burnetii ankyrin repeat domain-containing protein family is heterogeneous,

with C-terminal truncations that influence Dot/Icm-mediated secretion. J Bacteriol 2009,191(13):4232–4242.PubMedCrossRef 13. Pan X, Luhrmann A, Satoh A, Laskowski-Arce MA, Roy CR: Ankyrin repeat proteins comprise Dynein a diverse family of bacterial type IV effectors. Science 2008,320(5883):1651–1654.PubMedCrossRef 14. Luhrmann A, Nogueira CV, Carey KL, Roy CR: Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein. Proc Natl Acad Sci USA 2010,107(44):18997–19001.PubMedCrossRef 15. Maturana P, Graham JG, Sharma UM, Voth DE: Refining the plasmid-encoded Type IV secretion system substrate repertoire of Coxiella burnetii . J Bacteriol 2013,195(14):3269–3276.PubMedCrossRef 16. Beare PA, Larson CL, Gilk SD, Heinzen RA: Two systems for targeted gene deletion in Coxiella burnetii . Appl Environ Microbiol 2012,78(13):4580–4589.PubMedCrossRef 17.