961 (.01) 0.886 (.007) 0.892 (0.007) B>W, H Femoral neck BMAD, g/cm3, mean (SE) 0.217

(.003) 0.190 (.002) 0.201 (0.002) B>H>W B black, W white, H Hispanic, NS nonsignificant, SE standard error, BMI body mass index, DMPA depot medroxyprogesterone acetate, BMC bone mineral content, BMD bone mineral density, BMAD bone mineral apparent density aOne-way analysis of variance with Bonferroni correction was used for continuous variables and chi-squared tests were used for categorical variables bOnly those who were ever pregnant were included as denominator cClose relatives (mother, sister, grandmother, or aunt) lost height (gotten shorter) as they grew older dClose relatives (mother, sister, grandmother, or aunt) suffered a broken hip, wrist, spine, or shoulder Wortmannin mw after the age of 45 BMC, BMD, and BMAD were transformed to natural logarithms (ln) for analysis. Since there were significant interactions

between the main explanatory variables of weight/height and BMC/BMD/BMAD, separate multiple linear regression models for each race were performed. A multiple linear regression model with logarithms of spine BMC [ln(SBMC)] as the dependent variable showed significant relationships with height and months of prior DMPA use among black women (Table 2). A similar model with logarithms of femoral neck BMC [ln(FNBMC)] as the dependent variable also identified weight as a predictor. Predictors of ln(SBMC) and ln(FNBMC) among white women were age and height, and age, weight, height, and amount of weight-bearing exercise, respectively. The predictors among Hispanic women

for ln(SBMC) were age at menarche, LY333531 clinical trial weight, and height, and for ln(FNBMC) weight, height, and alcohol use. Table 2 Correlates of spine and femoral neck bone mineral content (BMC) by race/ethnicity based on multiple regression models Characteristics either Black White Hispanic Co-efficient P value R 2 Co-efficient P value R 2 Co-efficient P value R 2 Spine BMC     0.38     0.21     0.28  Age (year) 0.0042 0.126   0.0051 0.029   0.0042 0.054    Age at menarche (year) −0.0104 0.083   −0.0087 0.140   −0.0140 0.004    Weight (kg) 0.0007 0.194   0.0010 0.052   0.0016 0.004    Height (cm) 0.0135 <0.001   0.0100 <0.001   0.0096 <0.001    Parity −0.0103 0.258   −0.0012 0.895   0.0097 0.179    DMPA use (months) −0.0013 0.020   0.0001 0.948   −0.0009 0.090    Pill use (months) 0.0002 0.575   −0.0004 0.153   0.0000 0.901    Weight-bearing exercise (>120 min/week) 0.0244 0.240   0.0090 0.610   −0.0055 0.729    Current smoker −0.0151 0.580   −0.0243 0.166   0.0016 0.933    Alcohol use (g/day) 0.0004 0.729   0.0002 0.708   −0.0004 0.777    Calcium (g/day) 0.0306 0.213   0.0010 0.968   −0.0067 0.780    Constant 1.8667 <0.001   2.3744 <0.001   2.4365 <0.001   Femoral neck BMC     0.41     0.41     0.29  Age (year) −0.0040 0.183   −0.0064 0.002   −0.0015 0.479    Age at menarche (year) −0.0062 0.346   −0.0008 0.882   −0.0063 0.193    Weight (kg) 0.0048 <0.001   0.0046 <0.001   0.0043 <0.001    Height (cm) 0.0057 0.001   0.