Arch Dis Child.
2011;96:1175–9.PubMedCrossRef 81. Pereira GL, Dagostini JM, Pizzol TS. Alternating antipyretics in the treatment of fever in children: a systematic review of randomized clinical trials. J Pediatr (Rio J). 2012;88:289–96.CrossRef 82. Saphyakhajon P, Greene G. Alternating acetaminophen and ibuprofen in children may cause parental confusion and is dangerous. Arch Pediatr Adolesc Med. 2006;160:757–8.PubMedCrossRef 83. Schmitt BD. Concerns over alternating acetaminophen and ibuprofen for fever. Arch Pediatr Adolesc Med. 2006;160:757–8.PubMedCrossRef 84. Moore RA, Straube S, Paine J, Derry S, McQuay HJ. Minimum efficacy criteria for comparisons between treatments using individual patient meta-analysis of acute pain trials: examples of etoricoxib, paracetamol, ibuprofen, Omipalisib ic50 and ibuprofen/paracetamol combinations after third molar extraction. Pain. 2011;152:982–9.PubMedCrossRef 85. Mullins ME, Empey M, Jaramillo D, et al. A prospective randomized study to evaluate the antipyretic effect of the combination of acetaminophen
and ibuprofen in neurological ICU patients. Neurocrit Care. 2011;15:375–8.PubMedCrossRef 86. de Vries F, Setakis E, van Staa TP. Concomitant use of ibuprofen and paracetamol and the risk of major clinical safety outcomes. Br J Clin Pharmacol. 2010;70:429–38.PubMedCentralPubMedCrossRef enough 87. Purssell E, While AE. Does the use of antipyretics in children who have acute infections prolong febrile illness? A systematic review and meta-analysis. J Pediatr. 2013;163:822–7.PubMedCrossRef ARN-509 chemical structure 88. Mahadevan
SB, McKiernan PJ, Davies P, Kelly DA. Paracetamol induced hepatotoxicity. Arch Dis Child. 2006;91:598–603.PubMedCentralPubMedCrossRef 89. Medicines and Healthcare products Regulatory Agency (MHRA). MHRA UK Public Assessment Report: Liquid paracetamol for children: revised UK dosing instructions have been introduced. 2011. http://www.mhra.gov.uk/home/groups/comms-ic/documents/websiteresources/con134921.pdf. Accessed May 2014. 90. National Institute for Health and Care Excellence (NICE). Clinical Knowledge Summaries: Feverish children-management. 2013. http://cks.nice.org.uk/feverish-children-management#!scenarioclarification. Accessed May 2014.”
“Key Points While a lack of CRT0066101 mouse compelling evidence for aggressive blood pressure (BP) targets in high-risk patients with hypertension has driven more relaxed target recommendations in the European Society of Hypertension/European Society of Cardiology 2013 guidelines for the management of arterial hypertension, substantial evidence exists that further cardiovascular (CV) benefits are available from more intensive BP lowering.