10 Therefore, we aimed to evaluate the potential factors which may affect extubation time in Shiraz, southern Iran. Materials and Methods In a retrospective study, we conducted a review of the

records of 334 eligible patients who underwent elective coronary artery bypass grafting (CABG) in 2008 in Kowsar Hospital, affiliated to Shiraz University of Medical Sciences, Shiraz, southern Iran. The study was approved by the University’s Ethics Committee. The patients’ demographic data and operative variables were extracted from the records. All patients scheduled for CABG surgery Inhibitors,research,lifescience,medical were enrolled in the study. We excluded patients with difficult intubation, severe acid base disturbance, neurological Inhibitors,research,lifescience,medical problems, and cardiovascular instability, and those who used intra-aortic balloon pump, had underwent emergency operation, or had another concomitant surgery. The anesthesia technique had been the same for all the patients. Balanced anesthesia was induced with 0.1-0.2 mg/kg intravenous midazolam, 0.1-0.25 µ/kg sufentanil, 0.1-0.15 mg/kg morphine, 1-2 mg/kg sodium thiopental, plus 0.08-0.12 mg/kg intravenous pancuronium for muscle relaxation. Anesthesia was maintained with isoflurane. Standard CABG had been performed by the same groups of surgeons and anesthesiologists throughout. The Inhibitors,research,lifescience,medical patients had been transferred to the ICU and extubated after

hemodynamic and respiratory stability. To determine factors associated with the extubation period, the patients were selected regarding extubation time. One group had an extubation time of equal or less than 6 hours (early extubation group) and another group had experienced Apitolisib in vivo longer extubation time (delayed extubation group). The Inhibitors,research,lifescience,medical extubation criteria were adequate ventilation

according to arterial Inhibitors,research,lifescience,medical blood gas analysis and full consciousness of the patients. Also hemodynamic parameters of the patients should be within normal limit. Data were presented as mean (±SD) or ratios as appropriated and analyzed using SPSS software, version 13 (Chicago, IL, USA). P value of <0.05 was considered as statistically significant. In univariate analysis, the differences were analyzed using t test for continuous variables and chi-square test for discrete variables. for Consequently, in multivariable analysis, multiple logistic analyses of variance were conducted to reveal predicting factors of delayed extubation. The dependent variable was group indicator (early or delayed group), with the factors as independent variables. Results We selected 167 patients with early extubation and 167 patients with delayed extubation time. We found a significant difference in age (P<0.001) and sex (P=0.032) between the patients with early and delayed extubation (univariate analysis, table 1). There were not significant differences in baseline data including ejection fraction (P=0.21) and risk factors (P=0.27) between the two groups (table 1).