16 [95% confidence interval 0.91-1.47] and hazard ratio: 1.31 [95% confidence interval 0.90-1.93], respectively for the highest HbA(1c) tertile compared with the lowest).

Conclusion: These results suggest that HbA(1c) does not significantly predict all-cause and cardiovascular mortality in non-diabetic community-dwelling older adults. (C) 2009 Elsevier B.V. All rights reserved.”
“We systematically investigate the characteristics of an electrical oscillation observed in two-terminal vanadium dioxide (VO2) devices. These oscillations are observed at room temperature in a simple electrical circuit without

inductive components. The GANT61 circuit is composed only of a dc voltage source, the VO2 device, and a standard resistor connected in series with the device. We explain why the observed oscillations BMS-345541 are a result of the percolative metal-to-insulator transition

(MIT) of VO2 and the coexistence of the metal and insulating phases. Specifically, oscillations are attributed to the construction and destruction of capacitive regions composed of regions of the semiconducting phase, (as dielectric material) and metallic phase electron carriers, induced by the MIT (as capacitor electrodes). Since the coexistence of these phases-and thus the capacitive regions-is destroyed by elevated temperature, the MIT oscillation is not explained in terms of significant heat input but rather in terms of a voltage-triggered effect. It is also discussed whether the current jump CP-456773 mw at the onset of the oscillations is driven by Mott physics or by Peierls physics relying on a structural phase transition. Furthermore, the electrical parameter space surrounding these oscillations is explored, and a generation window is identified. Within this generation window, the oscillation frequency can be continuously tuned by adjusting applied voltage or by an external circuit component, such as resistor or added capacitor. The frequency of oscillations can be increased up to >1 MHz.”
“Constitutively active, ‘oncogenic’ H-RAS can drive proliferation and transformation in human

cancer, or be a potent inducer of cellular senescence. Moreover, aberrant activation of the Ras pathway owing to germline mutations can cause severe developmental disorders. In this study we have generated transgenic zebrafish that constitutively express low levels, or can be induced to express high levels, of oncogenic H-RAS. We observed that fish carrying the integrated transgene in their germline display several hallmarks of Costello syndrome, a rare genetic disease caused by activating mutations in the gene H-RAS, and can be used as a model for the disease. In Costello-like fish, low levels of oncogenic H-RAS expression are associated with both reduced proliferation and an increase in senescence markers in adult progenitor cell compartments in the brain and heart, together with activated DNA damage responses.