, 2010). van Wyk (2001) have emphasized Venetoclax clinical trial that due to the spread of resistant parasite populations to most of the anthelmintics, the FAMACHA© method was introduced as a new technique to support parasite control using target selective treatment. The method is based on the principle of the correlation between the eye mucous colour and

the hematocrit values (level of anaemia), identifying animals that are able to withstand infections by Haemonchus contortus. Only animals that have marked clinical symptoms of helminthiasis have to be treated, leaving untreated those who have no clinical anaemia ( Molento et al., 2004). Using this approach one would allow the survival of an anthelmintic sensitive parasite population to persist on the environment, without being exposed to anthelmintic treatment, reducing the selection pressure towards resistance. However, the applicability of the FAMACHA© method is limited because it requires a percentage of H. contortus in the herd greater than 60% and needs trained technicians to perform the readings ( van Wyk and Bath, 2002). This method has been developed for sheep and only extended to goats, requiring studies to refine and prove its efficiency in these animals ( Molento et al., 2004 and Vilela Selleckchem Androgen Receptor Antagonist et al., 2008). Therefore, this study aimed to evaluate the FAMACHA© method as an auxiliary strategy for the

control of gastrointestinal helminthiasis of naturally infected dairy goats in an important resource-poor area of the semiarid region of Paraíba state, Brazil. The study was conducted in 63 farms, 56 in Passagem, five in Quixabá and two in Cacimba de Areia, in the semiarid area of Paraíba state, Northeastern Brazil (Fig. 1). The region has a rainy season from January

to May (when occurs 90% of annual rainfall) and a dry season from June to December. The annual temperature average is 30.6 °C, ranging from 28.7 to 32.5 °C. The vegetation is predominantly composed by the Caatinga biome (Vilela et al., 2008). Fifty dairy goats, 1–4 year-old, from each farm were used (3 farms/month) totaling 1800 animals. The experiment was done between May 2009 and April 2010. The total dairy goats Adenylyl cyclase were represented by 53% as Saanen, 32% Toggenburg and 15% Anglo-Nubian. All farms had a similar semi-intensive raising system, restricting the usage of anthelmintic treatments for at least four months before the visits. The parasitological examinations were at the Laboratory of Parasitic Diseases of Domestic Animals, at the Universidade Federal de Campina Grande, city of Patos, Brazil, according to Gordon and Whitlock (1939), for the counting of eggs per gram (EPG) of faeces. Larval culture was performed according to Roberts and O’Sullivan (1950). Blood samples were collected for determining the packed cell volume (PCV).