9% [95% CI 16 3-25 5](p<0 0001) Also a significant heterogeneity

9% [95% CI 16.3-25.5](p<0.0001). Also a significant heterogeneity was found (i-square 89% p<0.000). Even when different types

and doses of agents were considered (high vs. low volume PEG vs. sodium phosphate vs. Mg citrate), the rate of “excellent or good” bowel cleansing was always superior in the split group with a difference ranging from 11.6% to 30.0% GDC-0068 datasheet (p<0.001). Such a superiority was progressively lost with increasing time between the last dose of laxative intake and the beginning of the colonoscopy (Tab. 1). Regardless of types and doses of laxative used, the split regimen is the best colon cleansing method; this advantage is progressively lost with increasing time interval between the last dose of purge intake and the beginning of colonoscopy (Table 1). Table 1. time interval between last dose of purge and colonoscopy (in hours) No. of treatment arms No. of patients

(spli group/no split group) difference C.I. 95% Significance of tests < 2 11 1131/1098 0.271 0.182 to 0.360 z= 5.99 "
“The updated 2012 international AZD2281 consensus guidelines for the management of intraductal papillary mucinous neoplasms (IPMN) and pancreatic mucinous cystic neoplasms (MCN) recommend endoscopic evaluation of all cysts determined to have “worrisome features” and surgical resection for all cysts deemed to have “high risk stigmata”. The purpose of this study was to evaluate the accuracy of the Sendai 2012 EUS criteria for detection of malignant pancreatic cystic lesions in the context of routine clinical care. We conducted a retrospective multi-center analysis on data from 5 sites (2 academic referral centers and 3 community-based EUS facilities) that performed EUS for evaluation of all pancreatic cysts from 2006-2011. We included only cases with either histologic Adenosine diagnosis or at least 1 year clinical surveillance data available. Patients with history of acute or chronic pancreatitis were excluded. Malignancy was defined as

high-grade dysplasia or more advanced histology or findings of metastatic disease on surveillance imaging. Accuracy of the revised Sendai criteria was assessed as sensitivity (sens), specificity (spec), positive- (ppv) and negative predictive values (npv) for presence of any of the following features on EUS imaging: i) presence of mural nodules, ii) solid component, iii) main pancreatic duct size ≥ 5 mm and iv) cytology suspicious or positive for malignancy. Overall performance of the criteria was evaluated by calculation of the area under the receiver operator characteristic curve (AUC) using multivariable logistic regression assigning 1 point for the presence of each of the aforementioned criteria. A total of 544 patients with pancreatic cysts (median age 68 years [IQR 58, 75], 65.8% women) were included in the study analysis. There were 13 (2.4%) malignancies identified. Carcinoembryonic antigen was available in 299 (54.9%) of cases: mean CEA 1129 ng/mL, standard deviation 8675.

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