Cancer Res 2006,66(17):8462–9468.PubMedCrossRef 42. Ehrlich CHIR-99021 mw M: DNA methylation in cancer: too much, but also too little. Oncogene 2002,21(35):5400–5413.PubMedCrossRef 43. Takekawa M, Saito H: A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell 1998,95(4):521–530.PubMedCrossRef 44. Harkin DP, Bean JM, Miklos D, Song YH, Truong VB, Englert C, Christians FC, Ellisen LW, Maheswaran S, Oliner JD, Haber DA: Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1. Cell 1999,97(5):575–586.PubMedCrossRef 45. Kuwahara A, Yamamori M, Kadoyama K, Nishiguchi K, Nakamura T, Miki I, Tamura T, Okuno T, Omatsu
H, Sakaeda T: Effects of plasma concentrations of 5-fluorouracil on long-term survival after treatment with a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal
squamous cell carcinoma. J Exp Clin Cancer Res 2011,30(1):94.PubMedCrossRef 46. Koo DH, Park SI, Kim YH, Kim JH, Jung HY, Lee GH, Choi KD, Song HJ, Song HY, Shin JH, Cho KJ, Yoon DH, Kim SB: Phase II study of use of a single cycle of induction chemotherapy and concurrent chemoradiotherapy containing capecitabine/cisplatin followed by surgery for patients with resectable esophageal squamous cell carcinoma: long-term follow-up data. Cancer Chemother Pharmacol 2011,28(11):1750–1755. 2011 47. Yokota T, Hatooka S, Ura T, Abe T, Takahari D, Shitara K, Nomura M, Kondo C, Mizota A, Yatabe Y, Shinoda M, Muro K: Docetaxel plus 5-Fluorouracil and Cisplatin (DCF) Induction Chemotherapy LY294002 price for Locally Advanced Borderline-resectable T4 Esophageal Cancer. Anticancer Res 2011,31(10):3535–3541.PubMed 48. Piacentini P, Durante E, Trolese A, Mercanti A, Bonetti A: Weekly Taxotere and cisplatin with continuous-infusion 5-fluoruracil for the treatment of advanced gastric and esophageal cancer: a prospective, observational, single-institution experience. Gastric Cancer ID-8 2012,15(1):106–10.PubMedCrossRef 49. Gopisetty G, Ramachandran K, Singal R: DNA methylation
and apoptosis. Mol Immunol 2006,43(11):1729–1740.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions BxW made all the experiment and wrote the manuscript. BlY and CC devised the experiment. BH, WxZ and YP made statistical data. MZ, ZkX and JqT made language amend of the manuscript. NY and XmZ checked and approved the manuscript. All authors read and approved the final manuscript.”
“Background Despite recent progress in treatment, lung cancer remains the leading cause of cancer deaths in both women and men throughout the world [1]. Not all patients with lung cancer benefit from routine surgery and chemotherapy. This is especially true for those with primary non-small cell lung cancer (NSCLC), the most common malignancy in the thoracic field, where such therapies have been tried with limited efficacy [2].