Cohen, et.al. reported mortality rates of 84%–91% among GS-4997 chemical structure patients who were anticoagulated prior to an intracranial bleed [10]. Mina, et.al. compared anticoagulated patients to matched controls and found an absolute

increase in mortality of 30% among the anticoagulated patients [11]. Another study evaluated the effect of rapid reversal of coagulopathy. Patients who underwent a rapid, protocolized reversal of coagulopathy had a 38% absolute reduction in mortality compared to historical controls [12]. Although these studies clearly indicated higher risks of death and disability among patients exposed to anticoagulants before the time of injury, they do not speak to the risks of administration of anticoagulants in a delayed GSK2399872A purchase fashion. While many thrombotic complications can be treated without anticoagulation, there are specific scenarios in which

anticoagulation has the potential to markedly improve a treatment regimen. Inferior vena cava (IVC) filters are the mainstay of treatment of both DVT and PE in patients with a contraindication to anticoagulation [3]. There are certain situations, however, Pexidartinib datasheet in which IVC filters are not adequate. The filters do not prevent propagation of a thrombus that has already embolized to the pulmonary vasculature. A saddle PE requires very little propagation to result in lethal shock, so anticoagulation in this population is critical. Similarly, the long term morbidity of phlegmasia cerulean dolens is reduced with anticoagulation. Further, there is a small, but defined, risk of thrombosis of the IVC after placement of a filter [6]. This situation also requires anticoagulation. A final venous thrombosis that that is not amenable to treatment with an intravascular filter is an upper extremity DVT. Superior vena cava filters are uncommon and would lead to fatal intracranial swelling in the event of filter thrombosis.

There is only one report that has attempted to define the optimal treatment regimen of DVT or PE after intracranial hemorrhage [6]. This report focused on non-traumatic hemorrhage, so the generalizability may be limited. The authors conducted a review of the literature and were unable to develop firm recommendations. Blunt cerebrovascular injury is another event that may require anticoagulation despite the presence of an intracranial hemorrhage [13]. Dissection of the carotid or vertebral arteries Fludarabine supplier can lead to disabling or fatal stroke events, which may be prevented by adequate anticoagulation. Although much of the focus of treatment has shifted to antiplatelet regimens, there is a role for heparin in select cases. Our data suggests that therapeutic anticoagulation can be safely given to select patients with blunt cerebrovascular injury and intracranial hemorrhage. Patients with mechanical cardiac valves represent a significant challenge to trauma surgeons [14–17]. The risk of artificial valves appears to be the highest in patients with a cage/ball valve in the mitral position.