(1) In vivo study Sprague-Dawley (SD) rats had been split into control group, H2S exposure team (publicity to 300×10-6 H2S for 3 hours), Xuebijing control group (Xuebijing shot 4 mL/kg , twice a day, for 3 days), and Xuebijing intervention group (H2S exposure after pretreatment of Xuebijing shot) according to arbitrary quantity technique, with 6 rats in each group. At different time things (0, 6, 12 and 24 hours) following the model had been made effectively, the total protein content in plasma and bronchoalveolar lavage fluid (BALF) of rats were detected respectively, plus the pulmonary permeability list (PPI) was calculated (PPI = protein content in BALF/protein content in plasma), lung dry/wet weight ratio (W/D) had been detected, and claudin-5 mRNA expression in lung tissue had been meease of claudin-5 protein had been decreased (claudin-5/β-actin 0.68±0.04 vs. 0.38±0.03, P less then 0.01). Conclusions Xuebijing injection may improve pulmonary vascular barrier purpose in ALI by upregulating claudin-5 expression.Objective To compare the cuff pressure and leakage volume additionally the relevant complications of filling the tracheal tube cuff by minimum air leakage strategy and cuff pressure manometer technique after endotracheal intubation, in order to provide theoretical foundation for customers who was intubated to have proper cuff force. Practices A prospective randomized controlled study ended up being conducted. 100 clients admitted into the department of crucial attention medication associated with the Fifth Center medical center in Tianjin from December 2015 to June 2019 were enrolled. Based on the arbitrary number table technique, the patients were divided into the experimental group and control group, with 50 patients in each group. After effective endotracheal intubation, all patients had been positioned in a supine position because of the head for the sleep raised by 30 degree angle. The experimental team used the minimum air leakage technique, and used the cuff pressure manometer to get the cuff force. In the control group, cuff force ended up being preserved at 25-30 cmH2O (1 ptimal cuff force is essential for stopping VAP and decreasing airway problems. The minimal environment leakage method makes the clinical gotten Drug Screening endotracheal intubation cuff force more precisely, with less environment leakage, effective and safe, and it’s also worthy of clinical promotion.Objective To systematically review proof when it comes to aftereffect of convalescent plasma and immunoglobulin on treatment of serious intense respiratory problem (SARS), and further provide good advice in the remedy for coronavirus disease 2019 (COVID-19). Techniques Clinical studies of convalescent plasma and immunoglobulin when you look at the treatment of SARS were gathered from many different databases such PubMed, Cochrane Library, Web of Science, Embase, CNKI, VIP, Wanfang, and CBM from November 2002 to March 2020. Two researchers separately screened the literature, extracted the data, and assessed the possibility of prejudice in line with the nationwide institute for health and clinical quality case series quality scale, and systematically assessed the outcomes. Results a complete of 10 medical researches, including 212 customers, were fundamentally included. There were 4 case show researches, 5 case reports and 1 case-control research. Many researches were with reduced or really low high quality. The organized analysis indicated that 107 clients administered convalescent plasma and 16 patients utilized immunoglobulin throughout the remedy for SARS. Forty-nine patients were definitely not treated with all the preceding two methods, and the remaining 40 clients are not reported plainly. The therapy of convalescent plasma and immunoglobulin could both enhance the symptoms and lower the death (12 passed away), & most SARS patients improved, while 11 SARS patients whom failed to have the overhead therapies died. Conclusions Convalescent plasma and immunoglobulin were effective on relieving signs and symptoms of SARS customers. Nonetheless, due to low quality and lacking of control group, convalescent plasma and immunoglobulin is combined with care to treat COVID-19 clients.Objective To provide a reference for extracorporeal membrane layer oxygenation (ECMO) inter-hospital transport during coronavirus infection 2019 (COVID-19), on the basis of the transportation experience of 6 patients with serious H1N1 influenza virus pneumonia utilizing ECMO. Methods Clinical data of patients with extreme H1N1 influenza virus pneumonia implemented by ECMO in the First Affiliated Hospital of Wannan healthcare university from October 2018 to December 2019 had been retrospective analyzed, including basic information, ECMO transport distance, time, clinical parameters before and after ECMO, such as the customers’ oxygenation list (PaO2/FiO2), breathing price (RR), pulse blood air saturation (SpO2), arterial blood carbon dioxide limited stress (PaCO2), and pH value, different problems during transportation, technical ventilation time, patients’ prognosis and other indicators. Knowledge through the areas of personal protection, transport process and equipment, group collaboration, mid-transit monitoring, quality control, etc., transmission took place health employees. To reach good therapeutic impact, the main experience was to select proper time and mode of ECMO; undamaged transportation vehicles and equipment to cut back or avoid technical problems; the efficient management of respiration and blood supply during the transport to prevent ventilation-associated lung damage (VALI) and really serious hypoxemia; the correct room for the transfer group to rapidly deal with various vital situations; and private protection to avoid illness.