“Purpose: To retrospectively determine the detection rates, clinical stages, and short-term patient survival
for all unsuspected cancers identified at screening computed tomographic (CT) colonography, including both colorectal carcinoma (CRC) and extracolonic malignancies.
Materials and Methods: From April 2004 through March 2008, prospective colorectal and extracolonic interpretation was performed in 10 286 outpatient adults (5388 men, 4898 women; mean age, 59.8 years) undergoing screening CT colonography at two centers selleck in this institutional review board-approved, HIPAA-compliant study. For all histologically proved, clinically unsuspected cancers detected at CT colonography that were identified at retrospective review of the medical records, the stage of disease, treatment, and clinical outcome were analyzed. Benign neoplasms (including advanced colorectal adenomas), symptomatic lesions, and tumors without pathologic proof were excluded. Statistical analysis was performed with Fisher exact test and two-sample z test.
Results: Unsuspected cancer was confirmed in 58 (0.56%) Epigenetics inhibitor patients (33 women, 25 men; mean age,
60.8 years), which included invasive CRC in 22 patients (0.21%) and extracolonic cancer in 36 patients (0.35%). Extracolonic malignancies included renal cell carcinoma (n = 11), lung cancer (n = 8), non-Hodgkin lymphoma (n = 6), and a variety of other tumors (n = 11). Cancers in 31 patients (53.4%) were stage I or localized. At the most recent clinical follow-up (mean, 30.0 months +/- 11.8 [standard deviation]; range, 12-56 months), three patients (5.2%) had died of their cancer.
Conclusion: The overall detection rate of unsuspected cancer is approximately one per 200 asymptomatic adults undergoing routine screening CT colonography, including about one invasive CRC per 500 cases and one extracolonic cancer per 300 cases. Detection and treatment at
an early presymptomatic stage may have contributed to the favorable outcome. (C) RSNA, 2010″
“To meet with the requirement of proton exchange membrane in direct methanol fuel cells (DMFCs), sulfonated poly(aryle ether ketone sulfone)/ polypyrrole (SPAEKS/Ppy) composite membranes with different contents of Ppy were prepared by chemically in situ polymerization. FT-IR spectra suggested that the sulfonic groups on Vorinostat manufacturer SPAEKS copolymers interacted with N groups of Ppy. SEM pictures showed that the Ppy particles were uniformly distributed throughout the SPAEKS membranes matrix. The composite membranes showed good thermal stability, low water uptake, and high proton conductive capability. The methanol diffusion coefficient (1.18 x 10(-7) cm(2)/s) of the composite membrane with 15% Ppy was much lower than that of pure SPAEKS membrane (8.52 x 10(-7) cm(2)/s). The composite membranes showed very good potential usage in direct methanol fuel cells (DMFCs). (C) 2010 Wiley Periodicals, Inc.