In line with the present results, previous work has also suggested that a 3-day exposure to concentrated PM2.5 ambient air particles exerts no significant effects on hematologic parameters in dogs ( Clarke et al., 2000), although some elemental components of concentrated PM2.5 air showed associations with white and red blood

cells counts. http://www.selleckchem.com/products/pexidartinib-plx3397.html On the other hand, compromised rats could show significant systemic changes when exposed to ambient air pollution ( Cassee et al., 2005 and Elder et al., 2004), e.g., 2-day PM2.5-exposure increased fibrinogen concentration in the blood of spontaneously hypertensive rats ( Cassee et al., 2005). It is noteworthy that these authors exposed the animals to higher levels of concentrated air particles than in the present study, which could account for the most prominent systemic effect observed. Moreover, 7 days of exposure to PM2.5 levels 10 μg/m3 above the annual

standard suggested by World Health Organization was associated with high levels of plasma IL-1β, TNF-α, endothelin-1 and adhesion molecules in children ( Calderón-Garcidueñas et al., 2008). In summary, the present findings show that in vivo exposure to concentrated urban air PM2.5 from São Paulo city for 15 consecutive days impairs endothelium-dependent vasodilatation of pulmonary arteries in healthy rats and is associated with reduced eNOS protein expression, oxidative stress and high TNF-α levels in these arteries. The pulmonary artery abnormalities were not accompanied by changes in systemic blood cells count, in plasma cytokines levels or in coagulation cascade. Altogether, Selleckchem MDV3100 the functional and molecular changes observed in pulmonary artery provide new evidence to elucidate the mechanisms underlying the trigger of cardiopulmonary diseases in response to urban ambient air pollution. In the present study we focus on the daily exposure to concentrated PM2.5 at a level that, when normalized over 24 h, is within the

limits next of PM2.5 concentration predicted by World Health Organization air quality guidelines (25 μg/m3). It emphasizes that exposure to low levels of PM2.5 predicted to do not cause harm to the cardiovascular system could still have effects and thus should be studied further. The authors declare that there are no conflicts of interest. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP Grants 02/09804-0 and 08/54212-0) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (Brazil). L.V.R. and P.H.S. are research fellows from CNPq. “
“En el artículo «III Reunión de consenso de la Sociedad Española de Trasplante. Hepático (SETH). Hepatitis C, trasplante hepático de donante vivo, calidad de los injertos hepáticos y calidad de los programas de trasplante hepático» (Gastroenterol Hepatol. 2011;34:641-659) de la Sociedad Española de Trasplante Hepático, se ha añadido por error como autor a J. Ignacio Herrero, cuando la autoría pertenece al colectivo Sociedad Española de Trasplante Hepático. J.