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ERH developed the concept for this manuscript and wrote the sections on caloric intake, macronutrients, psychosocial issues and “peak week”. AAA wrote the sections on nutrient timing and meal frequency. PJF wrote the abstract, methods, limitations, and the section on dietary supplementation. All authors read and approved the final manuscript.”
“Background Colon cancer is a result of an evolving process characterized by alterations of multiple genes and dysregulated cell signal transduction pathways. It has been well known that mutations of key genes in the Wnt/β-catenin signaling pathway play an important role in the occurrence and development of colon cancer [1, 2]. Under physiological conditions, Wnt contributes to the stabilization of β-catenin. Once stabilized, β-catenin accumulates and migrates to the nucleus.

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