It’s been recently identified that GSK3B may possibly determine oocyte meiosis, in particular the metaphase I/II transition, being part of the MAPK3/1 and MAPK14 pathways in oocytes and cumulus cells in cattle. GSK3 is demonstrated to be described as a important regulator of cellular destiny and a participant in the differentiation events during embryonic development through its involvement reversible Chk inhibitor in the Wnt signal transduction pathway GSK3 phosphorylates b catenin, the central element in Wnt signaling that is responsible for the transmission of Wnt signals to the nucleus. Phosphorylation of b catenin by GSK3B contributes to ubiquitination of b catenin and its subsequent degradation in proteasomes. But, when GSK3B is inactivated by phosphorylation, w catenin translocates to the nucleus and stimulates the transcription of Wnt genes. It’s been shown that there’s a relationship between a suitable regulation of Wnt signaling and normal embryo development. Chromoblastomycosis For instance, bovine embryos which develop past the 16 cell stage showed a proper distribution of b catenin in all blastomeres and a suitable morphology. But, the deletion of specific Wnt genes in the mouse, Caernorhabditis elegans, and Drosophila in strong changes within the phenotypes. Lithium, among the best drugs for the treatment of bipolar disorder, exerts its effects through the inhibition of GSK3 by two components that work in concert. First, there’s a direct inhibitory effect by lithium on GSK3 through competition with magnesium ions for binding to GSK3. Subsequently, lithium pifithrin triggers indirect inhibition of GSK3 by increasing the inhibitory serine phosphorylation of GSK3 Lithium can imitate the actions of Wnt/Wingless on t catenin/Armadillo in mammalian and Drosophila cells. Treatment with lithium has remarkable effects on morphogenesis throughout early development of diverse organisms. In zebrafish, lithium exposure creates excessive shield formation and intense hyper dorsal development. In Xenopus, it causes an extension of dorsal mesoderm, leading to imitation of the axis or, in extreme cases, entirely dorsalized embryos. A short treatment with lithium chloride in the two or eight cell stage causes mouse embryos to develop axial problems similar to those noticed in some strains that adversely affect gastrulation. Repeated mitosis during cleavage needs a careful regulation of microtubule dynamics for assembling a spindle apparatus that properly segregates chromosomes. In somatic cells, Wakefield et al. reported that GSK3 exists along the period of spindle microtubules, being phospho GSK3 plentiful at the centrosome and spindle poles. More over, inhibition of GSK3 leads to a rise in the duration of faulty chromosome alignment and mitotic microtubules, suggesting that GSK3 activity is associated with managing the total amount of microtubule dynamics during mitosis.