Demands such as this which arise through the development and application of our model description construction and software tools provide impetus 5 for the development of the key Physiome Project/VPH software structure. With the development of higher pc software level access to the different model databases and as the repository CDK inhibition curators increase the level of annotation of the models therein, there is scope to help our net based presentation environment to directly access the models. That the data captured in the complete design information. For altering the distribution of transport proteins using tubule segments or example, noticing the change in luminal sodium focus when changing the gradient in the bathing media. Such performance would greatly improve the application with this device as a teaching aid. We have developed a framework for the extensive description of biophysically comprehensive multi MAPK pathway cancer range physiological types. We use appropriate community dened types and technologies to represent the mathematical models and associated annotations, where possible. For the portions of the multi level model, that are not in a position to be represented using current models, custom methods have been developed by us for representing the data. These custom techniques are now getting used to help so that you can ensure our complete model descriptions develop community requirements within the Physiome/ VPH jobs are fully represented using community dened formats. The ability will be greatly improved by this to share and reuse types expressed using this framework one of the scientic area. In a demonstration of our model description framework, we’ve implemented a multiple level computational model of Immune system the renal nephron segments. By using this type, we have been able to reproduce simulation trials from the literature at the transport protein, whole cell and nephron tubule spatial scales. Some preliminary investigations have been also performed by us by using this product. We have also produced a prototype user interface that’s able to present the detailed description of the variable range nephron type within an active webbased environment. We are currently developing the nephron model and the user interface to incorporate more functional sections of the nephron and the associated ion transfer kinetics. Work is also underway to would greatly increase the exibility for people of our web environment to communicate with the variable level models. In future versions of our screen, users will have the ability IEM 1754 dissolve solubility to edit the model points which form the detailed model description, changing boundary conditions, for instance. Moreover, with access to the model databases, it would be possible to do queries for alternative models that could be automatically taken into the multi scale model. This project is funded by way of a Vice Chancellors Strategic Progress Fund from The University of Auckland. T. T. is supported by an Auckland Doctoral Scholarship. E. M. H. is supported by the Department of Physiology, University of Otago.