Taddei CR, Moreno AC, Fernandes Filho A, Montemor LP, Martinez MP: Prevalence of secreted autotransporter toxin gene among diffusely adhering Escherichia coli isolated from stools of children. FEMS Microbiol Lett 2003, 227:249–253.CrossRefPubMed 22. Guignot J, Chaplais C, Coconnier-Polter MH, Servin AL: The secreted autotransporter toxin, Sat, functions as a virulence factor in Afa/Dr diffusely adhering Escherichia coli by promoting lesions in tight junction of polarized Quisinostat order epithelial cells. Cell Microbiol 2007, 9:204–221.CrossRefPubMed 23. Betis F, Brest P, Hofman V, Guignot J, Kansau I, Rossi B, Servin A, Hofman

P: Afa/Dr diffusely adhering Escherichia coli infection in T84 cell monolayers induces increased neutrophil transepithelial migration, which

in turn promotes cytokine-dependent upregulation of decay-accelerating factor (CD55), the receptor for Afa/Dr adhesins. Infect Immun 2003, 71:1774–1783.CrossRefPubMed 24. Brest P, Betis F, Cuburu N, Selva E, Herrant M, Servin A, Auberger P, Hofman P: Increased rate of apoptosis and diminished phagocytic ability of human neutrophils infected with Afa/Dr diffusely adhering Escherichia Metabolism inhibitor coli strains. Infect Immun 2004, 72:5741–5749.CrossRefPubMed 25. Arikawa K, Meraz IM, Nishikawa Y, Ogasawara J, Hase A: Interleukin-8 secretion by epithelial cells infected with diffusely adherent Escherichia coli possessing Afa adhesin-coding genes. Microbiol Immunol 2005, 49:493–503.PubMed 26. Weiss-Muszkat M, Shakh D, Zhou Y, Pinto R, Belausov E, Chapman MR, Sela S: Biofilm formation by and

multicellular behavior of Escherichia coli O55:H7, an atypical EPZ015666 clinical trial enteropathogenic strain. Appl Environ Microbiol 2010, 76:1545–1554.CrossRefPubMed 27. Huang DB, Dupont HL: Enteroaggregative Escherichia coli: an emerging pathogen in children. Semin Pediatr Infect Dis 2004, 15:266–271.CrossRefPubMed 28. Pereira AL, Silva TN, Gomes AC, Araújo AC, Giugliano LG: Diarrhea-associated biofilm formed by enteroaggregative Escherichia coli and aggregative Citrobacter freundii: a consortium mediated by putative F pili. BMC Microbiol 2010, 10:57.CrossRefPubMed 29. Ghigo JM: Natural conjugative plasmids induce bacterial biofilm development. Nature 2001, 412:442–445.CrossRefPubMed 30. May T, Okabe S: Escherichia Amisulpride coli harboring a natural IncF conjugative F plasmid develops complex mature biofilms by stimulating synthesis of colanic acid and Curli. J Bacteriol 2008, 190:7479–7490.CrossRefPubMed 31. Bäckhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon JI: Host-bacterial mutualism in the human intestine. Science 2005, 307:1915–1920.CrossRefPubMed 32. Chowdhury SR, King DE, Willing BP, Band MR, Beever JE, Lane AB, Loor JJ, Marini JC, Rund LA, Schook LB, Van Kessel AG, Gaskins HR: Transcriptome profiling of the small intestinal epithelium in germfree versus conventional piglets. BMC Genomics 2007, 8:215.CrossRefPubMed 33. Kelly D, King T, Aminov R: Importance of microbial colonization of the gut in early life to the development of immunity.