“The central role of adipose tissue in the development of cardiovascular and metabolic pathology
has been highlighted by the discovery of mediators (adipokines) secreted by adipose tissue and their involvement in the regulation of various biological processes. In light of recent experimental data, cross-talk between adipose tissue and the adrenal gland, particularly via the mineralocorticoid aldosterone, has been proposed. Aldosterone can induce adipogenesis, and human white adipose tissue is reported to release as-yet-uncharacterized Veliparib chemical structure factors that stimulate adrenocortical steroidogenesis and alclosterone production. These data could provide new insights into the pathophysiology of obesity-related disorders, including hypertension and alclosterone excess, with further studies necessary for confirming and better defining such adipose-adrenal interactions.”
“This paper is concerned with the theoretical study of two-dimensional peristaltic flow of power-law fluids in three layers with different viscosities. The analysis is carried out under low Reynolds number and long wavelength approximations. The shapes of the interfaces are described by a system of nonlinear algebraic equations which are solved numerically as streamlines. It
is found that the non-uniformity in the intermediate and peripheral SC75741 order layers diminishes when the viscosity of the intermediate layer is increased and that of the outermost layer is kept unaltered for both the pseudo-plastic and dilatant fluids. Similar are the observations when the viscosity of the outermost layer is increased and that of the intermediate layer is kept this website fixed. The flow rate increases with the viscosities of the peripheral and the intermediate layers but the viscosity of the outermost layer is more effective. However, the knowledge of the effect of the viscosity of the intermediate layer facilitates us to achieve the required flow rate without disturbing the outermost layer. An increase in the flow behaviour
index too favours larger flow rates. The trapping limits increase with the viscosity of the intermediate layer but decrease with the viscosity of the outermost layer and the flow behaviour index. Thus, a medicinal intervention that creates a more viscous intermediate layer and reduces pseudo plasticity may reduce constipation. (C) 2011 Elsevier Ltd. All rights reserved.”
“Ketamine, a noncompetitive N-methyl-D-aspartic acid (NMDA) receptor antagonist, is capable of triggering excessive glutamate release and subsequent cortical excitation which may induce psychosis-like behavior and cognitive anomalies. Growing evidence suggests that acute ketamine administration can provoke dose-dependent positive and negative schizophrenia-like symptoms.