(C) 2010 Elsevier B.V. All rights reserved.”
“This paper reports the construction
of a novel multi-sensitive chemically crosslinked injectable hydrogel with strong mechanical strength by modifying Pluronic F127 responsive against temperature, pH and redox potential. Crosslinked polymer between benzaldehyde grafted Pluronic (P-A) and amine end capped Pluronic having disulfide linkage (P-B) have been synthesized and characterized with 1 H NMR spectroscopy and GPC. The hydrogel under physiological conditions significantly altered sol-gel transition behaviors with much lower critical gelation concentrations and temperatures, compared to Pluronic hydrogels. The rheological characterization demonstrated that the moduli of the hydrogels were able to be tuned depending on molecular weight as well as pH, redox and temperature click here conditions.”
“A new series of peptidomimetic pseudo-prolyl-homophenylalanylketones were designed, synthesized and evaluated for inhibition of the Plasmodium falciparum cysteine proteases Selleckchem SNX-5422 falcipain-2 (FP-2) and falcipain-3 (FP-3). In addition, the parasite killing activity of these compounds in human blood-cultured P. falciparum was examined. Of twenty-two (22) compounds synthesized, one peptidomimetic comprising a homophenylalanine-based a-hydroxyketone linked Cbz-protected
hydroxyproline (39) showed the most potency (IC50 80 nM against FP-2 and 60 nM against FP-3). this website In silico analysis of these peptidomimetic analogs offered important protein-ligand structural insights including the role, by WaterMap, of water molecules in the active sites of these protease isoforms. The pseudo-dipeptide 39 and related compounds may serve as a promising direction forward in the design of competitive inhibitors of falcipains for the effective treatment of malaria. (c) 2014 Elsevier Ltd. All rights reserved.”
“Anionic polymerizations of acrylates possessing 1-pyrenyl (Py1), 1-naphthyl (Np1), 2-naphthyl (Np2), and 2-fluorenyl (Fl2) groups
as alpha-substituents were investigated as well as the properties of the obtained polymers. Py1 and Np1 did not undergo polymerization, whereas Np2 and Fl2, annulated alpha-phenylacrylates at 3,4-position of the phenyl group, afforded homo-oligomers and alternating copolymers with methyl methacrylate (MMA). The oligomer of Fl2 [oligo(Fl2)] exhibited strong excimer emission in diluted solution. In contrast, dominant monomer emission was observed for the alternating copolymer with MMA [ poly(Fl2-co-MMA)]. In the alternating copolymer, MMA units could function as spacers preventing the association of pendant fluorene moieties to suppress the excimer formation. (C) 2014 Wiley Periodicals, Inc.”
“ProblemIn twin pregnancies, factors that influence total umbilical cord IgG concentration and IgG transfer ratio are not well known.