Collectively, these findings indicate that additional benefits of vedolizumab treatment may accrue between weeks 6 and 10, regardless of previous TNF antagonist response, and could be associated with effects of an additional vedolizumab dose at week 6 or with the incremental effect of time on the drug’s ability to exert a therapeutic benefit. Similar findings have been observed with natalizumab induction DNA Synthesis inhibitor therapy, 6 which suggests that a gradual onset

of efficacy may be an attribute of drugs that modulate lymphocyte trafficking. This observation may help with the optimization of vedolizumab induction therapy in real-world settings. The lack of statistical significance of primary outcome results contrasts with the GEMINI 2 induction study results in patients with previous TNF antagonist failure.24 However, several patient characteristics and design parameters differed between these 2 studies (eg, differences in upper CDAI score cut-off values, defined by entry criteria,

and in mean CDAI scores, and re-randomization Stem Cell Compound Library at week 6 in GEMINI 2). In a prespecified subgroup analysis of patients from GEMINI 2 with previous TNF antagonist failure, the proportion of patients with week 6 clinical remission was similar between vedolizumab-treated (10.5%) and placebo-treated groups (4.3%; treatment difference, 6.2%; 95% CI, -9.1% to 21.3%). In a prespecified subgroup analysis of TNF antagonist–naive patients from GEMINI 2, the week 6 remission rate was higher with vedolizumab (17.4%) than with placebo (9.2%; treatment difference, 8.2%; 95% CI, -1.4% to 17.9%). The week 6 treatment difference in patients with previous TNF antagonist failure was similar in GEMINI 3 (3.0%) and GEMINI 2 (6.2%), whereas the week 6 treatment difference in TNF antagonist–naive patients was larger in GEMINI 3 (19.2%) than in GEMINI 2 (8.2%). Observed differences in week 6 remission rates between overall populations of the

2 studies may be attributable to variations between 2 otherwise similar patient populations, including proportions of patients with previous exposure to 1, 2, or 3 TNF antagonists (GEMINI 2, 47.6%; GEMINI 3, 75.7%). The upper bound of patients’ CDAI scores (GEMINI 2, 450; GEMINI 3, 400) or random variation could have accounted for the observed differences in subgroup SPTBN5 analyses of week 6 remission rates among TNF antagonist–naive patients. Effects of vedolizumab induction therapy were modest overall, and maintenance effects were not evaluated in this short-term study; however, the modest efficacy of vedolizumab induction therapy in GEMINI 2 was contrasted by the pronounced benefit of vedolizumab maintenance therapy over the course of 52 weeks. Among vedolizumab induction responders in GEMINI 2, week 52 clinical remission occurred in 39.0% (P < .001) and 36.4% (P = .004) of patients who continued vedolizumab every 8 and 4 weeks, respectively, and in 21.6% of patients who were assigned randomly to switch to placebo during maintenance.