Concerted efforts should be made to reduce system level factors that hinder the implementation of evidence-based care.”
“Using a model of perinatal brain lesions induced by lipopolysaccharide and hypoxia/ischemia, we hypothesized that interleukin-2 (IL-2), a neurotoxic cytokine, was enhanced within injured brains. We showed that lipopolysaccharide and hypoxia/ischemia
enhanced both Alisertib manufacturer intracerebral IL-2 mRNA and protein levels, with a maximum increase upon lipopolysaccharide and hypoxia/ischemia. The lack of detectable T lymphocytes suggested the synthesis of IL-2 by neural cells. Lipopolysaccharide and hypoxia triggered IL-2 synthesis by cultured microglia with a
peak after exposure to lipopolysaccharide and hypoxia. Double-labeling showed, in vivo and in vitro, that IL-2 immunoreactivity was colocalized with a microglia/macrophage marker. These results disclosed the ability of microglia to produce IL-2 and also suggest the implication of IL-2 in neural cell death triggered by perinatal lipopolysaccharide and hypoxia/ischemia exposures.”
“Purpose: This study is an assessment of the acceptability and short-term educational efficacy of interactive spaced education compared to web based teaching cases within the compact time frame of a clinical clerkship.
Materials and Methods: All 237 third-year students completing their 3-month surgery clerkships at 2 medical schools were asked to complete a urology online-education program
covering 4 core topics of benign prostatic hyperplasia, erectile dysfunction, prostate KU-60019 price cancer and screening with prostate specific antigen. Students were stratified by clinical site and randomized to 1 of 2 cohorts. Students in cohort A received interactive spaced education on prostate cancer/prostate specific antigen and web based teaching on benign prostatic hyperplasia/erectile dysfunction. click here Students in cohort B received interactive spaced education on benign prostatic hyperplasia/erectile dysfunction and web based teaching on prostate cancer/prostate specific antigen. A validated 28-item test on all 4 topics was administered at the end of the 10-week program.
Results: No statistically significant differences in end-of-program test scores were observed between cohorts in the topics of prostate cancer/prostate specific antigen with 87.6% (SD 12.9) for cohort A (interactive spaced education) and 82.4% (SD 19.6) for cohort B (web based teaching) (p = 0.25). Similarly there was also no statistically significant difference in test scores in the topics of benign prostatic hyperplasia/erectile dysfunction with 79.5% (SD 15.9) for cohort A (web based teaching) and 82.1% (SD 14.7) for cohort B (interactive spaced education, p = 0.28).