Conversely, Ro 61-8048 ic50 a sedentary lifestyle would be associated with an increased risk of colon cancer in men and women [8]. Fermented food is an important component of traditional diets, both for its nutritional value and its prophylactic and therapeutic properties [13]. However, its consumption

in Brazil remains at a low level, due probably to the relatively high price of such products [14]. Research has also demonstrated that the commensal lactic acid bacterium from the human gut, Enterococcus (formerly Streptococcus) Mdivi1 mw faecium CRL 183, if consumed in a fermented soy product, has several beneficial effects on the health. These include appreciable cholesterol-reducing activity, stimulation of the immune system, anticarcinogenic activity and inhibition of post-menopausal osteoporosis [15–19]. In view of the

possible benefits of ingesting E. faecium and the potential role of physical exercise in the prevention of certain types of cancer, we decided to test the effects of consuming soy product fermented with E. faecium CRL 183, while engaging (or not) in physical exercise (moderate or intense), on the formation of ACF in rats injected with DMH. Methods Animal maintenance and administering of products Tideglusib mw Eighty 4-week-old male Wistar SPF rats, average weight 200 g, were obtained from the central

animal facility at the State University of Campinas (CEMIB, UNICAMP-SP, Brazil). The animals were housed for 8 weeks in boxes Org 27569 within a vivarium cabinet (Alesco®, Brazil) equipped with air filtration, controlled temperature (22 ± 1°C) and a dark:light cycle of 12:12 h. During the experiment, the rats had free access to sterile water and sterilized commercial rat chow (Purina®, Brazil), with the following composition: 23% protein, 49% carbohydrate, 4% fat, 5% fiber, 7% ash and 6% vitamin C. The products being tested were administered daily by gavage, at 3 mL/kg body weight (b.w.) per day, throughout the 8-week period. All animal procedures were submitted to the Research Ethics Committee of the School of Pharmaceutical Sciences, UNESP at Araraquara (SP, Brazil), who approved the experimental protocol.

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