This progressive remodeling contributes to stress urinary incontinence/pelvic organ prolapse by altering normal tissue architecture and mechanical properties.”
“Introduction: Recent clinical studies have demonstrated that Yi-Gan San (YGS, Yokukan-San in Japanese), a Chinese herbal medicine, alleviates various dementia-related symptoms. However, Chinese herbal medicines have rarely been investigated scientifically and the underlying mechanism of YGS remains uncertain. In this study, we investigated the effect of YGS on beta amyloid protein (A beta)-induced cytotoxicity in a primary culture of rat cortical neurons.
Methods: Cortical neurons prepared
from rat embryos were exposed to A beta in the presence or absence of YGS. The protective effect of YGS was measured
as the % of control (unexposed neurons) by using MTT assay and LDH assay.
Results: A beta significantly QNZ order decreased the number of surviving cortical neurons at a dose of 20 mu M and higher. In the presence of 20 mu M A beta, YGS concentrations of 10(-5) g/L (W/V) and higher significantly increased the number of viable neurons.
Conclusion: Our study demonstrated a neuroprotective effect of Yi-Gan San against AB-induced cytotoxicity. learn more Since according to traditional herbal medicine beliefs, YGS most likely exerts its clinical effects not through a single constituent but as a mixture of several herbal ingredients, the true mechanism of this neuroprotective action remains unclear. However, our results
suggest that this Chinese herbal medicine might be a valuable treatment for clinical symptoms associated with dementia having fewer side effects and possible additional neuroprotective effects in the elderly. (c) 2008 Elsevier Inc. All rights reserved.”
“Purpose: The Leibovich prognosis score was developed as a prognostic tool for metastatic disease after radical nephrectomy for clear cell renal cell carcinoma using pathology review. However, selleck kinase inhibitor this scoring system has never been externally validated. We externally validated its prognostic accuracy using routine pathology reports.
Materials and Methods: We retrospectively evaluated data from the routine pathology records of 1,754 consecutive patients with nonmetastatic clear cell renal cell carcinoma operated on between 1984 and 2006 at a single tertiary academic center. Clear cell renal cell carcinoma cases were categorized as 0 to 11 by the Leibovich prognosis score and further stratified into low, intermediate and high risk groups. Metastasis-free survival was assessed using the Kaplan-Meier method. To evaluate the prognostic impact a multivariate Cox regression model was used and prognostic accuracy was determined using Harrell’s concordance index.
Results: Median followup was 82 months (IQR 39-142). Metastasis developed in 375 of the 1,754 patients (21.4%).