We would also like to thank Carolyn Foster for her assistance in preparation of the manuscript. Financial support was provided by the Polish Ministry of Science and Higher Education

(Grant No. N N405 623138). Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. References Banerjee PS, Sharma PK (2012) New antiepileptic agents: structure–activity relationships. Med Chem Res 21:1491–1508CrossRef buy Epacadostat Barton ME, Klein BD, Wolf HH, White HS (2001) Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy. Epilepsy Res 47:217–227PubMedCrossRef Bialer M, White HS (2010) Key factors in the discovery and development of new antiepileptic drugs. Nat Rev Drug Discov 9:68–82PubMedCrossRef Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS (2013) Progress report on new antiepileptic drugs: a summary of the Eleventh Eilat Conference (EILAT XI). Epilepsy Res 103:2–30PubMedCrossRef Brodie MJ (2001) Do we need any more antiepileptic drugs? Epilepsy Res 45:3–6PubMedCrossRef Brown WC, Schiffman DO, Swinyard EA, Goodman LS (1953) Comparative

assay of an antiepileptic drugs by psychomotor seizure test and minimal buy ACP-196 electroshock threshold test. J Pharmacol Exp Ther 107:273–283PubMed Dawidowski M, ABT-737 in vitro Herold F, Chodkowski A, Kleps J, Szulczyk P, Wilczek M (2011) Synthesis and anticonvulsant activity of novel FER 2,6-diketopiperazine derivatives. Part 1: perhydropyrrole[1,2-a]pyrazines. Eur J Med Chem 46:4859–4869PubMedCrossRef

Dawidowski M, Herold F, Chodkowski A, Kleps J (2012a) Synthesis and anticonvulsant activity of novel 2,6-diketopiperazine derivatives. Part 2: perhydropyrido[1,2-a]pyrazines. Eur J Med Chem 48:347–353PubMedCrossRef Dawidowski M, Herold F, Turło J, Wilczek M, Chodkowski A, Gomółka A, Kleps J (2012b) Synthesis of bicyclic 2,6-diketopiperazines via a three-step sequence involving an Ugi five-center, four-component reaction. Tetrahedron 68:8222–8230CrossRef Demharter A, Hörl W, Eberhardt H, Ugi I (1996) Synthesis of chiral 1,1′-iminodicarboxylic acid derivatives from α-amino acids, aldehydes, isocyanides, and alcohols by the diastereoselective five-center-four-component reaction. Angew Chem Int Ed 35:173–175CrossRef Dunham MS, Miya TA (1957) A note on a simple apparatus for detecting neurological deficit in rats and mice. J Am Pharm Assoc Sci Ed 46:208–209CrossRef Kaminski RF, Livingood MR, Rogawski MA (2004) Allopregnanolone analogs that positively modulate GABA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice. Epilepsia 45:864–867PubMedCrossRef Kwan P, Brodie MJ (2000) Early identification of refractory epilepsy.