Orthotopic neobladders were used to divert the urine.
At the time of last follow-up, patients were interviewed in a standard fashion to evaluate urinary, bowel and sexually related symptoms. Results. During the follow-up period (mean 72 months, range 33-129) five patients developed metastases and died of bladder cancer. Four men were diagnosed with concomitant prostate cancer. Complete day-time continence was reported in 17/20 (85%) patients. Complete nocturnal continence was seen in 10/20 (50%) men. A total of 20/21 (95%) were sexually active following prostate-sparing cystectomy. Conclusion. Prostatic capsule- and seminal-sparing cystectomy appears to combine acceptable eFT-508 inhibitor oncological outcome with satisfactory function of the lower urinary tract; however, standard
radical cystectomy still represents the gold standard.”
“Objective: Changes in T1 rho and T2 magnetic resonance relaxation times have been associated with articular cartilage degeneration, but similar relationships for meniscal tissue have not been extensively investigated. This work examined relationships between T1 rho and T2 measurements and biochemical and mechanical properties across regions of degenerate human menisci.
Design: Average T1 rho and T2 relaxation times were determined for nine regions each of seven medial and 13 lateral menisci from 14 total knee replacement patients. Sulfated glycosaminoglycan (sGAG), collagen and water this website Kinase inhibitor Library contents were measured for each region. Biomechanical measurements of equilibrium compressive, dynamic compressive and dynamic shear moduli were made for anterior, central and posterior regions.
Results: T1 rho and T2 times showed similar regional patterns, with longer relaxation times in the (radially) middle region compared to the inner and
outer regions. Pooled over all regions, T1 rho and T2 times showed strong correlations both with one another and with water content. Correlations with biochemical content varied depending on normalization to wet or dry mass, and both imaging parameters showed stronger correlations with collagen compared to sGAG content. Mechanical properties displayed moderate inverse correlations with increasing T1 rho and T2 times and water content.
Conclusion: Both T1 rho and T2 relaxation times correlated strongly with water content and moderately with mechanical properties in osteoarthritic menisci, but not as strongly with sGAG or collagen contents alone. While the ability of magnetic resonance imaging (MRI) to detect early osteoarthritic changes remains the subject of investigation, these results suggest that T1 rho and T2 relaxation times have limited ability to detect compositional variations in degenerate menisci. (C) 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.