Key Word(s): 1. SMA; 2. Duodenal obstruction; 3. Vomiting; 4. Epigastric pain; Presenting Author: SHI HUI Additional Acalabrutinib Authors: WU BENYAN Corresponding Author: SHI HUI, WU BENYAN Affiliations: 301 Hospital Objective: Intestinal ischemia, including ischemic colitis and acute mesenteric ischemia, causes significant morbidity and mortality. Rapid and accurate diagnosis is essential to improve the prognosis and quality of life of patients with intestinal ischemia. This study aims at improving diagnosis of intestinal ischemia, by measuring serum intestinal fatty
acid binding protein (I-FABP) and D-lactate levels. Methods: Patients with a clinical diagnosis of acute abdomen were recruited for this trial over a 15-month period. Serum I-FABP and D-lactate levels were measured in 237 eligible patients by an enzyme-linked immunosorbent assay using a monoclonal antibody. Results: Of the 237 patients, 46 were diagnosed with intestinal ischemia, 191 were diagnosed with other diseases. The mean serum I-FABP and D-lactate levels in the patients with intestinal ischemia was 149.74 ± 57.81 ng/ml
and 52.73 ± 26.46 ug/ml, which was significantly higher than that in patients with non-ischemic bowel disease (36.78 ± 11.25 ng/ml, 15.58 ± 5.17 ug/ml) and the healthy control group (8.33 ± 6.25,10.58 ± 7.27 ng/ml). Cutoff values for I-FABP (93.07 ng/ml) and D-lactate (34.28 ug/ml) showed clinically relevant positive likelihood ratios of 3.08, 2.62, and negative likelihood ratios of 0.26, 0.47 respectively. Conclusion: Serum I-FABP and D-lactate levels can improve MG-132 cost diagnosis for the efficient identification of patients with acute abdomen who are at risk of intestinal ischemia. Key Word(s): 1. intestinal ischemia; 2. I-FABP; 3. D-lactate; 4. biomarker; Presenting Author: WENJIA LIU Additional
Authors: JUN CAO Corresponding Author: JUN CAO Affiliations: Nanjing Drum Tower Hospital Objective: To analyze the clinical features and results of laboratory examine, hoping for understanding clearly of systemic the lupus erythematosus learn more (SLE) associated with intestinal p seudo obstruction (IPO) Methods: The clinical manifestations, laboratory and serologic abnormalities, internal organs involved, treatment and prognosis of 2 SLE with IPO and ascites were analyzed retrospectively. Results: Among the 2 cases of SLE with IPO, one case presented with IPO as the initialmanifestation of SLE, all presented with ascites,1 had hematological system involvement. All caseswere antinuclearantibody (ANA) positive, 1 had positive anti-dsDNA. C3 decreased in all the 2 cases. IPO responded readily to therapywithin one week in 2 patients. Conclusion: The early diagnosis and the treatment associating glucocorticoids with immune-suppressive is helpful to the disease controlling and prognosis improving. Key Word(s): 1.