These HGMNCs contained iron oxide (Fe3O4) AZD4547 mouse nanoparticles with an average particle size of about 22 nm, as observed by transmission electron microscopy. The dielectrical properties of the pure hydrogel (HG); the hydrogel loaded with iron

ions, or the hydrogel iron-ion composite (HGIC); and the HGMNCs were measured. These results suggest that HGMNCs exhibited higher dielectric constants compared to HG and HGICs. The curcumin loading and release characteristics were also measured for HG, HGIC, and HGMNC systems. These data revealed that there was a sustained release of curcumin from HGMNCs because of the presence of magnetic nanoparticles in the hydrogel networks. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 122: 1364-1375, 2011″
“Background: beta(2)-Adrenergic receptor (beta(2)-AR) is a susceptibility locus for hypertension, and polymorphisms at this site relate to salt sensitivity and low https://www.selleckchem.com/products/SB-202190.html plasma renin activity (PRA). The Dietary Approaches to Stop Hypertension (DASH) dietary pattern lowers blood pressure and appears to interact with the renin-angiotensin-aldosterone system (RAAS).

Objective: We hypothesized that the DASH diet associates with increased RAAS activity, and genotype status at beta(2)-AR G46A modifies this response.

Design: We genotyped participants in the DASH-Sodium study (n = 372) at beta(2)-AR G46A to determine the association with blood pressure, RAAS components, and consumption of

the DASH diet. We used 2-way mixed linear regression and an additive model for all primary analyses.

Results: Mean (+/-SEM) PRA was significantly higher in participants in the DASH group than in participants in the control group (0.68 +/- 0.03 compared with 0.54 +/- 0.03 ng . mL(-1) . h(-1), P = 0.002). Serum aldosterone, urinary aldosterone, and urinary potassium concentrations were also significantly higher in the DASH group (P, 0.01 for all). learn more We observed significant gene-diet interactions for changes in systolic blood pressure (SBP) and concentrations of aldosterone and urinary potassium (P for

interaction = 0.048, 0.017, and 0.001 for SBP and aldosterone and urinary potassium concentrations, respectively). There was an association between the A allele of beta(2)-AR G46A and greater blood pressure reduction and blunted aldosterone and PRA responses to the DASH diet.

Conclusions: Our results indicate that the DASH diet lowers blood pressure and increases PRA and aldosterone concentrations. There is an association between the G46A polymorphism of beta(2)-AR and blood pressure and RAAS responses to the DASH diet, which suggests that beta(2)-AR may be a genetic modifier of DASH-diet responsiveness. This trial was registered at clinicaltrials.gov as NCT00000608. Am J Clin Nutr 2010; 92:444-9.”
“Tb(6)Fe(1-x)C(o)xBi(2) (x = 0, 0.125, 0.250, 0.375) compounds have been synthesized, and the structural and magnetic properties are reported.

The comparison is done for an optimal value of the Seebeck coefficient in three, two, and one dimensions for Si/SiGe, Bi(2)Te(3), PbTe, and SrTiO(3) with various scattering mechanisms. It is then concluded that the increase in the magnitude of the integrated DOS and not the change in shape, as is commonly believed, to be most responsible for the increases in the power factor. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3359659]“
“T he carcinogenic risk induced by low doses of ionizing radiation is controversial. It cannot be assessed with epidemiologic methods alone because at low

doses the data are imprecise and often conflicting. Since the 1970s, the radiation protection community has estimated the risk of low doses by means of extrapolation from the risk assessed at high doses, generally by using the linear no-threshold (LNT) model.

The LNT relationship implies P5091 molecular weight proportionality between dose and cancer risk. This approach is based on one set of data and two hypotheses: (a) The relationship between

dose and DNA damage in vivo seems linear from 1 mGy to 100 Gy with use of H2AX foci as a marker for DNA double-strand breaks (DSBs)-however, this marker is not specific (1); (b) each DSB is hypothesized to have the same probability of inducing cell transformation, irrespective of the Sapanisertib quantity of DSBs present simultaneously in the cell; and (c) each transformed cell is hypothesized PD173074 to have the same probability of developing into an invasive cancer, irrespective of the dose delivered to the tissue. The advances during the past 2 decades in radiation biology, the understanding of carcinogenesis, and the discovery of defenses against carcinogenesis challenge the LNT model, which appears obsolete (2-6).

Life developed in a bath of ionizing radiation and solar ultraviolet radiation and created aerobic organisms requiring (a) defenses against the metabolically induced reactive oxygen species, (b) DNA repair, and (c) elimination of damaged cells. Several sets of data show the efficacy of these defenses to be much higher at

low than at high doses and for fractionated or protracted irradiation than for acute irradiation.

The LNT model was introduced as a concept to facilitate radiation protection (7). But the use of this model led to the claim that even the smallest dose (one electron traversing a cell) may initiate carcinogenesis-for instance, from diagnostic x-ray sources (8,9). This claim is highly hypothetical and has resulted in medical, economic, and other societal harm.

The French Academies report (10) concluded that the LNT model and its use for assessing the risks associated with low doses are not based on scientific evidence. In contrast, the Biological Effects of Ionizing Radiation (BEIR) VII report (11) and that of the International Commission on Radiological Protection (ICRP) (12) recommended the use of the LNT model.

Significant factors included: greater first intermetatarsal angle (pooled SMD = 1.5, CI: 0.88-2.1), longer first metatarsal (pooled SMD = 1.0, CI; 0.48-1.6), round first metatarsal head (RR: 3.1-5.4), and

lateral sesamoid displacement (RR: 5.1-5.5). Results for clinical factors (e.g., first ray mobility, pes planus, footwear) were less conclusive regarding their association with HV.

Conclusions: Although conclusions regarding causality cannot be made from cross-sectional studies, this systematic review highlights important factors to monitor in HV assessment and management. Further studies with rigorous methodology are warranted to investigate PXD101 clinical trial clinical factors associated with HV. (c) 2012 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.”
“Purpose of review

This review focuses on proteinase 3 (PR3), the

preferred target of antineutrophil cytoplasmic antibodies (ANCAs) in Wegener’s granulomatosis. Deciphering the molecular associations that PR3 can make with its cognate partners might help to understand its pathophysiological significance in Wegener’s granulomatosis and the potential role of ANCA as modulator of PR3 functions.

Recent findings

In neutrophils, PR3 is mainly localized within azurophilic granules but is also detected at the plasma membrane. Among PR3 partners (CD16, CD11b/CD18), CD177, a glycosylphosphatidylinositol (GPI)-anchored membrane protein is a potential receptor for PR3. In addition, PR3 can be selleck chemicals llc externalized at the plasma membrane at a very early stage of neutrophil apoptosis, find more in

the absence of degranulation. In these conditions, PR3 is associated with specific partners including phospholipidscramblase-II and calreticulin. Interestingly, apoptosis-induced PR3 membrane expression significantly impaired macrophage phagocytosis. This new role of PR3 acting as a ‘don’t eat me signal’ that delays neutrophil clearance might potentiate inflammation and autoimmunity.

Summary

Since PR3 membrane expression seems to represent a key element in the inflammatory and autoimmunity process, elucidation of the molecular basis of PR3 interaction with the plasma membrane or with receptor proteins led to the possibility of targeted therapy.”
“Objective: To systematically review the use of Quantitative sensory testing (QST) in pain characterisation (phenotyping) in Osteoarthritis (OA).

Methods: Six bibliographic databases (Medline, Embase, Amed, Cinahl, PubMed, Web of Science) were searched to identify studies published before May 2011. Data were extracted based on the primary site of OA, QST modalities, outcome measures and test sites. Standardised mean difference (SMD) and 95% confidence intervals (Cls) were calculated if possible. Publication bias was determined using funnel plot and Egger’s test. Heterogeneity was examined using Cochran Q test and 12 statistic. Random effects model was used to pool the results.

For each phantom, five anatomic regions

(head, neck, chest, abdomen, and pelvis) were considered. Monte Carlo simulations were performed for spiral scanning protocols with different voltages. Effective dose was computed by using ICRP publication 60 and publication 103 recommendations. The calculated effective doses were compared with those derived from the DLP by using previously published conversion factors.

Results: In general, conversion factors determined on the basis of Monte Carlo calculations led to lower values for adults with both ICRP publications. Values up to 33% and 32% lower than previously GSI-IX price published data were found for ICRP publication 60 and ICRP publication 103, respectively. For pediatric individuals, effective doses based on the Monte Carlo calculations were higher than those obtained from DLP and previously published conversion

factors (eg, for chest CT scanning in 5-year-old children, an increase of about 76% would be expected). For children, a variation in conversion factors of up to 15% was observed when the tube voltage was varied. For adult individuals, no dependence on voltage was observed.

Conclusion: Conversion factors from DLP to effective dose should be specified separately for both sexes and should reflect the new ICRP recommendations. For pediatric patients, new conversion factors specific for the spectrum used should be established. (C) RSNA, 2010″
“An approach for the preparation Selleck PP2 Panobinostat in vivo of homogenous SrTiO(3) (STO) thin films with unprecedented compositional control is presented. Nanolaminates of SrO and TiO(2) were

deposited at 300 degrees C by atomic layer deposition on bare silicon, as well as on ruthenium electrodes using metalorganic precursors [Ti(NEtMe)(4) (TEMATi),Sr(iPr(3)Cp)(2) (AbsoluteSr)]. Care was taken that the individual sublayers were grown with a number of subcycles well in the steady-state growth regime. This enabled linear composition tuning with the Sr: Ti pulse ratio, which is beneficial for process control. Still, a substrate-specific growth behavior was observed for the individual precursors leading to different cycle ratio/composition dependence for samples grown on Si as compared to Ru substrates. This could be attributed to specific nucleation conditions, which are most pronounced for the initial cycle, but also prevail throughout the film. The as-deposited layers are well separated and the sublayers are amorphous. Subsequent furnace-annealing generated polycrystalline cubic STO films, but also caused a severe distortion of the metal electrode/STO stack, due to interdiffusion. The latter was suppressed by optimized rapid thermal crystallization anneals. (C) 2011 American Institute of Physics. [doi: 10.1063/1.

However, effectiveness of PDT is limited due to an initiation of endogenous rescue response systems like heme oxygenase-1 (HO-1) in tumor cells. In recent NSC23766 molecular weight years, consuming of antioxidant supplements has become widespread, but the effect of exogenously applied antioxidants on cancer therapy outcome remains unclear. Thus, this study was aimed to investigate if exogenous antioxidants might decrease ROS-induced cytotoxicity in photodynamic

treatment. Lycopene, beta-carotene, vitamin C, N-acetylcysteine, trolox, and N-tert-butyl-alpha-phenylnitrone in different doses were administered to human melanoma cells prior exposure to photodynamic treatment.. Supplementation with vitamin C resulted in a significant decrease of the cell death rate, whereas the other tested antioxidants had no effect on cell viability and oxidative stress markers. The simultaneous Z-DEVD-FMK ic50 application of vitamin C with the HO-1 activity inhibitor zinc protoporphyrine IX (ZnPPIX) caused a considerable decrease of photodynamic treatment-induced cytotoxicity compared to ZnPPIX alone. It can be summarized that exogenously applied antioxidants do not have a leading role in the protective response against photodynamic treatment. However,

further studies are necessary to investigate more antioxidants and other substances, which might affect the outcome of photodynamic treatment in cancer therapy. (C) 2010 International Union of Biochemistry and Molecular Biology, Inc.”
“Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an inflammatory disorder of the peripheral nervous system with progressive

or relapsing signs in more than one limb, ending in prolonged periods of disability. There are no guidelines Ricolinostat cell line for anesthesia in this uncommon paralyzing disease. This report features a 19-year-old woman with CIDP scheduled for an elective cesarean section who had prolonged recovery of motor function after the administration of spinal anesthesia. Although a partial neural block in both feet persisted for 1 day, we conclude that spinal anesthesia is acceptable for cesarean delivery in CIDP-patients when reasonable precautions have been taken.”
“The detailed ultrastructural changes of uremia-induced hyperplastic parathyroid gland and the effects of current medical treatments for secondary hyperparathyroidism were investigated. Marked enlargement of parathyroid cell with accumulation of mitochondria and lipids and a significant increase in the thickness of the pericapillary area with increased fibrosis and appearance of fibroblast like cells were noted in the hyperplastic gland caused by uremia and phosphate retention. These ultrastructural changes and biochemical findings indicating hyperparathyroidism were significantly suppressed by all of the treatment using phosphate restriction, calcitriol, and cinacalcet. The characteristic ultrastructural changes, including the morphologic evidence of nodule formation, were indicated.”
“Bakhtiari savory (Satureja bachtiarica Bunge.

Results: aEuro integral Results showed elevated levels of Hsp70 mRNA and protein in SG cells of larvae immediately after gamma radiation exposure. The levels dropped

to basal values by 48 h in the recovery period.

Conclusions: aEuro integral The present study confirmed that radio-tolerant midge, C. ramosus expressed Hsp70 upon gamma radiation exposure and Hsp70 might be one of the gamma radiation-induced VS-6063 solubility dmso stress proteins required during the early stages of radiation stress management in aquatic midge larvae. This is the first report of its kind from the juvenile stage of any aquatic insect group.”
“The mechanism for suppressing the formation of abnormally large islands during the conventional quantum dot (QD) growth was investigated. In comparison of the periodic arsine interruption method to the conventional method, InAs QDs grown on GaAs substrate by metal organic chemical GSK1210151A order vapor deposition has a higher density and aspect ratio without large islands. The formation of large islands was related to the inhomogeneity in the nucleation and growth process of QDs. The surface modification from As-stabilized to In-stabilized surfaces during

arsine interruption modulated the surface energy and resulted in more homogeneous and simultaneous nucleation of QDs. The arsine interruption time was found to be a critical parameter for the homogeneous QD growth without abnormally large islands. (C) 2011 American Institute of Physics. [doi:10.1063/1.3624665]“
“We evaluated the effects of a standardized Labisia pumila var. alata (LPva) extract on body weight change, hydroxysteroid (11-beta)

dehydrogenase 1 (HSD11B1) expressions and corticosterone (CORT) level in ovariectomized (OVX) rats. The decoction of LPva has been used for generations among Malay women in Malaysia to maintain a healthy reproductive system.Thirty-six Sprague-Dawley OVX rats were treated orally with LPva extract (10, 20 or 50 mg/kg/day) or estrogen replacement (ERT) for 30 days. Sham operated rats were used as controls. Compared to untreated OVX rats, LPva-treated rats showed less weight gain and had significantly down-regulated HSD11B1 mRNA in liver tissues. HSD11B1 mRNA in adipose tissues AZD8186 increased by 55% (p < 0.05) in OVX rats but normalized in rats treated with LPva. Similarly, there was significant down-regulation (p < 0.05) of protein levels of HSD11B1 in both liver and adipose tissue of LPva and ERT groups, and CORT levels were significantly reduced in both groups of rats. This is the first study ever conducted to evaluate the beneficial effects of LPva in relation to weight gain caused by estrogen insufficiency. Results implied that the bioactive components in LPva extract affect not only HSD11B1 expressions in both adipose and liver tissues but also decrease circulating CORT.

Only one of these is shown to be beneficial to the overall efficiency of the device, while the other is at the expense of undesired high-order nonradiative recombination processes at high injection-levels. Covering a peak modal gain range of approximately 5 to 11 cm(-1) over injection-levels of 65 to 122 meV at 350 K, this dependence caused L(d) to change from 0.75 to 1.50 mu m, with the maximum occurring at 84 meV where the peak modal gain is 6 cm(-1). Decreasing the temperature

to 300 K reduced L(d) to <0.75 mu m over approximately the same injection-level range. (C) 2010 American Institute of Physics. [doi:10.1063/1.3471812]“
“Four Anlotinib datasheet of 9,10-dihydroanthracene-9,10-alpha,beta-alkyl succinates have been synthesized and used as internal electron donors in MgCl(2)-supported Ziegler-Natta catalysts. The performances of the catalysts on the propylene polymerization

have been investigated. The obtained polymers possess high-isotacticity and the polymerization activity is comparable with the catalysts using 9,9-bis(methoxymethyl)fluorene and diisobutyl phthalate as internal donor. With dimethoxydiphenylsilane as external donor, the catalysts for the polymerization of propylene exhibit satisfactory activities and are sensitive toward hydrogen. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 118: 1853-1858,2010″
“The primary aim of this study was to determine whether hippocampal asymmetries in fluorodeoxyglucose selleck compound (FDG) uptake on preoperative PET scans would predict post-temporal lobectomy verbal memory (VM) decline in patients with left temporal lobe epilepsy. A quantitative asymmetry index (AI) of uptake values within a hippocampal region of interest (ROI) was defined by an automated technique. No statistically significant effect of the hippocampal AI on the outcome measure, the pre- to postsurgical change in Logical Memory Percent Retention,

was evident. Post hoc analyses revealed that AIs of the superior and inferior temporal gyri approached significance, however, with relatively greater left-sided preoperative metabolism predicting better VM outcomes. This finding suggests reorganization of function and/or retained function of remaining tissue. Although hippocampal FDG-PET asymmetries did not significantly GF120918 nmr predict changes in VM, the predictive value of neocortical AIs should be further explored. Automated ROI parcellation provides a feasible tool for use in such investigations. (C) 2009 Elsevier Inc. All rights reserved.”
“The goal of this study was to investigate the dissolution behavior of styrene-butadiene block copolymers in biodiesel with an eye toward developing a promising method of plastic waste disposal by burning them with engine fuel. The dissolution kinetics was investigated by high-throughput Fourier transform infrared microscopy, and the effect of the dissolution temperature on the kinetics was quantified.

Materials and Methods: This prospective study was institutional review board approved and HIPAA compliant. Informed consent was obtained. One hundred sixty-three

subjects (39 with known hepatic steatosis, 110 with steatosis risk factors, 14 without risk factors) underwent proton MR spectroscopy and non-T1-weighted gradient-echo MR imaging of the liver. At spectroscopy, the reference FF was determined from frequency-selective measurements of fat and water proton densities. At imaging, FF was calculated by using two-, three-, or six-echo methods, with single-frequency and multifrequency fat signal modeling. The three-and six-echo methods corrected for T2*; the two-echo methods did not. For each imaging method, the fat estimation accuracy was assessed by using linear regression between the imaging

FF and spectroscopic FF. Binary classification accuracy of imaging was assessed at four reference spectroscopic thresholds (0.04, 0.06, 0.08, and 0.10 FF).

Results: BTK pathway inhibitor Regression intercept of two-, three-, and six-echo methods were -0.0211, 0.0087, and -0.0062 (P<.001 for all three) without multifrequency modeling and -0.0237 (P<.001), 0.0022, and -0.0007 with multifrequency modeling, respectively. Regression slope of two-, three-, and six-echo methods were 0.8522, 0.8528, and 0.7544 (P<.001 for all three) without multifrequency modeling and 0.9994, 0.9775, and 0.9821 with multifrequency modeling, respectively. Significant deviation of intercept and slope from 0 and 1, respectively, indicated systematic error. LY3023414 research buy NU7026 price Classification accuracy was 82.2%-90.1%, 93.9%-96.3%, and 83.4%-89.6% for two-, three-, and six-echo methods without multifrequency modeling and 88.3%-92.0%, 95.1%-96.3%, and 94.5%-96.3% with multifrequency modeling, respectively, depending on the FF threshold. T2* -corrected (three-and six-echo) multifrequency imaging methods had the overall highest FF estimation

and classification accuracy. Among methods without multifrequency modeling, the T2* -corrected three-echo method had the highest accuracy.

Conclusion: Non-T1-weighted MR imaging with T2* correction and multifrequency modeling helps accurately estimate hepatic proton-density FF at 3.0 T. (C)RSNA, 2011″
“Introduction and objectives: The treatment and control of cardiovascular risk factors both play key roles in primary prevention. The aim of the present study is to analyze the proportion of primary prevention patients aged 35-74 years being treated and controlled in relation to their level of coronary risk.

Methods: Pooled analysis with individual data from 11 studies conducted in the first decade of the 21st century. We used standardized questionnaires and blood pressure measures, glycohemoglobin and lipid profiles. We defined optimal risk factor control as blood pressure <140/90 mmHg and glycohemoglobin <7%. In hypercholesterolemia, we applied both the European Societies and Health Prevention and Promotion Activities Programme criteria.

The animals were killed 6 weeks after their surgery, and their parietal bones were harvested. The specimens were analyzed with microscopic computerized tomography (microCT) scans and histomorphometrics.

Results. The unfilled normobaric control bony defects did not heal, proving the critical-size nature of these defects. The presence of autogenous bone

or bone ceramic in the defects increased the bone volume fraction and bone mineral density of the defects AZD9291 (P < .001). The presence of a membrane in the ungrafted and autogenous bone grafted defects resulted in a decrease in the corrected bone volume fraction (P = .002) but not in the bone ceramic grafted defects (P = .580). Bony healing of defects where the membrane was unsupported was

compromised; the membrane did not maintain the desired bone regeneration volume with the unfilled and autogenous bone grafted groups. The PEG resorbable liquid membrane worked best with the bone ceramic material. HBO did not ameliorate the healing of the autogenous bone graft or ceramic filled defects in the 6-week time period of this study.

Conclusions. Although the PEG resorbable liquid membrane is easy to use and forms an occlusive layer, caution is recommended when using the membrane over an unsupported defect. HBO did not ameliorate bony healing with the membrane this website at the early 6-week time point. The authors recommend future assessment with HBO at the 12-week time point. (Oral Surg Oral Med Oral LGX818 Pathol Oral Radiol Endod 2010; 109: 372-384)”
“Industrial hemp fibers were treated with a 5 wt % NaOH, 2 wt % Na(2)SO(3)

solution at 120 degrees C for 60 min to remove noncellulosic fiber components. Analysis of fibers by lignin analysis, scanning electron microscopy (SEM), zeta potential, Fourier transform infrared (FTIR) spectroscopy, wide angle X-ray diffraction (WAXRD) and differential thermal/thermogravimetric analysis (DTA/TGA), supported that alkali treatment had (i) removed lignin, (ii) separated fibers from their fiber bundles, (iii) exposed cellulose hydroxyl groups, (iv) made the fiber surface cleaner, and (v) enhanced thermal stability of the fibers by increasing cellulose crystallinity through better packing of cellulose chains. Untreated and alkali treated short (random and aligned) and long (aligned) hemp fiber/epoxy composites were produced with fiber contents between 40 and 65 wt %. Although alkali treatment generally improved composite strength, better strength at high fiber contents for long fiber composites was achieved with untreated fiber, which appeared to be due to less fiber/fiber contact between alkali treated fibers. Composites with 65 wt % untreated, long aligned fiber were the strongest with a tensile strength (TS) of 165 MPa, Young’s modulus (YM) of 17 GPa, flexural strength of 180 MPa, flexural modulus of 9 GPa, impact energy (IE) of 14.

The relative position of the four

contacts is deduced from the size of the contacts and the inter-contact distance. Sagittal and coronal reconstructions along the electrode direction should be considered for the identification of the four electrode contacts. CT offers a useful alternative to post-operative MRI.”
“Background: Measuring body surface potentials in the assessment of the electrical activity of the heart is the most commonly used noninvasive method for diagnosing cardiac arrhythmias. Paroxysmal atrial fibrillation (PAF) patients have disturbed cardiac electrophysiology AZD6738 price but the detailed characteristics of atrial activation on the body surface are unknown. Methods: P waves from 60 sites on the body surface were

analyzed from 10 PAF patients in sinus rhythm (PAF group) and 10 healthy controls GSK1210151A order (HC group). Evolution of atrial depolarization was described qualitatively by maps of P-wave amplitudes. P-wave dipole evolution was described quantitatively by measuring the changing location (body site) and amplitude of the dipole positive and negative pole peaks. Results: Both groups exhibited similar dipolar structure with an area of positive and an area of negative potentials. Over the depolarization cycle, there were significant changes in the location of the dipole with the positive pole rotating anteriorly right to left by two electrode sites (10 cm) (P = 0.001). There were significant differences between groups with the positive pole in PAF offset to the right of the chest by 0.43 (0.38) strips compared to HC (P <

Tubastatin A manufacturer 0.007). Compared to controls, the PAF group positive poles reached peak amplitude sooner (49 [11] ms vs 65 [14] ms, P = 0.012) and negative poles reached peak amplitude later (74 [13] ms vs 62 [8] ms, P = 0.019). Conclusion: Atrial depolarization is characterized by a single dipole with time-varying amplitude and orientation with significant differences in dipole trajectory between patients with PAF and HCs. (PACE 2012;00:18)”
“In this study we analyzed Spanish Post-Heart-Transplant Tumour Registry data for adult heart transplantation (HT) patients since 1984. Median post-HT follow-up of 4357 patients was 6.7 years. Lung cancer (mainly squamous cell or adenocarcinoma) was diagnosed in 102 (14.0% of patients developing cancers) a mean 6.4 years post-HT. Incidence increased with age at HT from 149 per 100 000 person-years among under-45s to 542 among over-64s; was 4.6 times greater among men than women; and was four times greater among pre-HT smokers (2169 patients) than nonsmokers (2188).